Results 71 to 80 of about 2,321,208 (237)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Sustainable development and UK faith groups : two sides of the same coin? : a survey of UK faith communities’ sustainable development activities and next steps for the future [PDF]
, 2012 English language version of 'Datblygu cynaliadwy a grwpiau ffydd y DU : dwy ochr yr un geiniog? : arolwg o weithgareddau datblygu cynaliadwy cymunedau ffydd y DU a’r camau nesaf ar gyfer y dyfodol'.A survey of UK faith communities’ sustainable ...
World Wildlife Fund UK +1 more
core +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Optimizing Cutting Fluid Use via Machine Learning in Smart Manufacturing for Enhanced Sustainability
LubricantsHigh temperatures generated during machining can lead to undesirable outcomes such as surface deterioration, subsurface damage, tool wear, and shortened tool life.
Halit Süleyman Özdüzgün +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Advanced Techniques for Monitoring, Simulation and Optimization of Machining Processes [PDF]
, 2011 In today’s manufacturing industry, pressure for productivity, higher quality and cost saving is heavier than ever. Surviving in today’s highly competitive world is not an easy task, contemporary technology updates and heavy investments are needed in ...
Keshari, Anupam
core +1 more source
Design and analysis of the internally cooled smart cutting tools with the applications to adaptive machining [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Adaptive machining with internally cooled smart cutting tools is a smart solution for industrial applications, which have stringent manufacturing ...
Bin Che Ghani, Saiful Anwar
core +4 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
LubricantsIn today’s industrial applications, cutting fluids have attained prime importance due to their all-round features, including increase of tool life by lubrication of the tool at the tool–workpiece interface.
Aneesh Mishra +5 more
doaj +1 more source