Results 61 to 70 of about 2,800 (262)

Optimizing sustainable machining for magnesium alloys: a comparative study of GRA and TOPSIS

Cogent Engineering
This study delves into a comparative analysis of two multi-criteria decision analysis methods, Grey Relational Analysis (GRA) and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS), to fine-tune sustainable machining parameters ...
M. Atif Saeed, Faraz Junejo, Imran Amin
doaj   +1 more source

Causal machine learning for sustainable agroecosystems

CoRR
In a changing climate, sustainable agriculture is essential for food security and environmental health. However, it is challenging to understand the complex interactions among its biophysical, social, and economic components. Predictive machine learning (ML), with its capacity to learn from data, is leveraged in sustainable agriculture for applications
Vasileios Sitokonstantinou, Emiliano Díaz Salas Porras, Jordi Cerdà-Bautista, Maria Piles, Ioannis Athanasiadis 0001, Hannah Kerner, Giulia Martini, Lily-belle Sweet, Ilias Tsoumas, Jakob Zscheischler, Gustau Camps-Valls   +10 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Holistic Perspective on Sustainable Machining of Al6082: Synergistic Effects of Nano-Enhanced Bio-Lubricants

Machines
This study investigates the performance of biobased and nano-additive lubricants for the sustainable machining of Al6082 alloy. The experiments were conducted in five different cutting environments: dry cutting, olive oil-based minimum quantity ...
Rüstem Binali, Mehmet Erdi Korkmaz, Mehmet Tayyip Özdemir, Mustafa Günay   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Substantiation of the Design Parameters of the Abrasive Wheel for Sharpening Woodworking Saws

Журнал інженерних наук
The sharpening of woodworking saws is a crucial operation in ensuring high-quality wood cutting. To avoid burns, burrs, and bending of the saw tooth during sharpening, it is necessary to provide an appropriate temperature regime in the contact area of ...
Lidiia Dziuba, Mariia Pylypchuk, Oksana Chmyr, Roman Pavliuk, Yuriy Rubinskyy   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Assessment of surface quality and damages induced during dry helical milling of hybrid composite fiber metal laminates

Materials Research Express
The present work investigates the effectiveness of helical milling for making holes with excellent surface quality in carbon fiber aluminum laminates (CARALL) under dry cutting conditions.
Satish Shenoy Baloor, Suleyman Cinar Cagan, Gururaj Bolar, Madhusudhan Balkundhi, Anoop Aroor Dinesh   +4 more
doaj   +1 more source

On the Use of Compressed Air and Synthetic Biodegradable Cutting Fluid to Enhance the Surface Quality of WAAM–CMT Manufactured Low-Alloy Steel Parts During Post-Processing Milling with Different Cooling–Lubrication Strategies

Journal of Manufacturing and Materials Processing
Additive manufacturing (AM) stands out for its variable applications in terms of material, quality, and geometry. Wire Arc Additive Manufacturing (WAAM) is remarkable for producing large parts in reduced times when compared to other AM methods.
Déborah de Oliveira, Marcos Vinícius Gonçalves, Guilherme Menezes Ribeiro, André Luis Silva da Costa, Luis Regueiras, Tiago Silva, Abílio de Jesus, Lucival Malcher, Maksym Ziberov   +8 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source