Results 51 to 60 of about 2,321,208 (237)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Cryogenic cooling-based sustainable machining

, 2020
Machinability is the most important indicator to measure the performance of any machining operation. Cutting force, surface roughness, tool wear, dimensional accuracy, and cutting temperature, etc. are the most important machinability indicators. Various
Bayraktar, Şenol, Senol Bayraktar
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Sustainable development in government 2008 : challenges for government [PDF]

, 2012
Our seventh annual SDiG assessment found good overall progress by the UK Government, especially on targets for water, waste and travel, though reductions in carbon emissions from offices were still not on track.Publisher ...
Sustainable Development Commission
core   +2 more sources

Advanced Optimization of Drilling Parameters in Composite Materials: A Topsis-Based Approach for Enhanced Manufacturing Precision

Journal of Natural Fibers
Drilling natural fiber composite materials is challenging due to their anisotropic and heterogeneous structure, which often leads to delamination, thermal damage, and poor surface finish. The key objective of this study is to optimize drilling parameters
Mustapha Arslane, Mohamed Slamani, Abdelmalek Elhadi, Salah Amroune, Ugur Köklü, Madani Grine, Borhen Louhichi, Sabbah Ataya   +7 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Optimizing sustainable machining for magnesium alloys: a comparative study of GRA and TOPSIS

Cogent Engineering
This study delves into a comparative analysis of two multi-criteria decision analysis methods, Grey Relational Analysis (GRA) and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS), to fine-tune sustainable machining parameters ...
M. Atif Saeed, Faraz Junejo, Imran Amin
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A Holistic Perspective on Sustainable Machining of Al6082: Synergistic Effects of Nano-Enhanced Bio-Lubricants

Machines
This study investigates the performance of biobased and nano-additive lubricants for the sustainable machining of Al6082 alloy. The experiments were conducted in five different cutting environments: dry cutting, olive oil-based minimum quantity ...
Rüstem Binali, Mehmet Erdi Korkmaz, Mehmet Tayyip Özdemir, Mustafa Günay   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source