Results 51 to 60 of about 4,579 (301)

A step towards sustainable machining through increasing the cutting tool utilization

, 2013
Machining is an important and widely spread manufacturing method which should not be neglected while striving towards sustainable production. Several previous articles have discussed sustainable machining and different approaches towards reaching this ...
Zhou, Jinming,, Gröntoft, Elias, Schultheiss, Fredrik,, Ståhl, Jan-Eric,, Lund University.   +4 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Advanced Techniques for Monitoring, Simulation and Optimization of Machining Processes

, 2011
In today’s manufacturing industry, pressure for productivity, higher quality and cost saving is heavier than ever. Surviving in today’s highly competitive world is not an easy task, contemporary technology updates and heavy investments are needed in ...
Keshari, Anupam
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A knowledge management framework to support product-service systems design [PDF]

, 2009
This paper presents a framework for knowledge reuse in a Product-Service Systems design scenario. The project aim is to develop a methodology to capture, represent and reuse knowledge to support product development in a collaborative enterprise ...
Kalta, Mohamad, Kalta, Mohammad Mohamad, Roy, Rajkumar, Kalta, M., Gao, James, Baxter, David, Doultsinou, Athanasia, Taylor, Publisher, Gao, James X.   +8 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Sustainable Drilling Strategies for Rivet Hole Formation in Nickel-Based Alloys for Aeronautical Applications

Journal of Manufacturing and Materials Processing
The formation of rivet holes is a critical step in aeronautical assembly, as hole quality directly influences the fatigue resistance and structural reliability of riveted joints. Nickel-based alloys, such as Inconel 625, present additional challenges due
José Manuel Sáenz de Pipaón, Amabel García-Domínguez, Juan Claver, Eva María Rubio   +3 more
doaj   +1 more source

Multi-Objective Optimization of Machining Parameters for Multi-Pass CNC Turning to Minimize Carbon Emissions, Energy, Noise and Cost

Jurnal Teknik Industri, 2021
Global warming is a huge environmental issue today. This is due to the high level of world carbon emissions. The manufacturing process accounts for 30% of the world's carbon emissions production.
Bening Maulina Fittamami, Eko Pujiyanto, Yusuf Priyandari   +2 more
doaj   +1 more source