Results 51 to 60 of about 28,107 (312)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Micro milling performance assessment of diamond-like carbon coatings on a micro-end mill [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Institution of Mechanical Engineers.In micro milling, unpredictable tool life and premature tool failures are the major constraints ...
Cheng, K, Wu, T
core   +1 more source

Comparative study of Sustainability Metrics for Face Milling AISI 1045 in different Machining Centers [PDF]

, 2020
Comunicación presentada a MESIC 2019 8th Manufacturing Engineering Society International Conference (Madrid, 19-21 de Junio de 2019)The objective of this study is to compare a set of sustainability metrics between different manufacturing resources ...
Abellán-Nebot, José V., AYABACA, CESAR
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Dry sliding friction and wear response of WC-Co hardmetal pairs in linearly reciprocating and rotating contact [PDF]

, 2011
This paper presents an experimental evaluation of friction and wear properties of WC-Co cemented carbides. A comparison is made between unlubricated rotating and linearly reciprocating pin-onplate sliding pairs. The plate specimens were WC-10wt%Co grades
Bonny, Koenraad, De Baets, Patrick, Lauwers, Bert, Malek, Olivier, Neis, Patric Daniel, Perez Delgado, Yeczain, Rodriguez Fereira, Vanessa, Vleugels, Jef   +7 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Sustainable Drilling Strategies for Rivet Hole Formation in Nickel-Based Alloys for Aeronautical Applications

Journal of Manufacturing and Materials Processing
The formation of rivet holes is a critical step in aeronautical assembly, as hole quality directly influences the fatigue resistance and structural reliability of riveted joints. Nickel-based alloys, such as Inconel 625, present additional challenges due
José Manuel Sáenz de Pipaón, Amabel García-Domínguez, Juan Claver, Eva María Rubio   +3 more
doaj   +1 more source

Multi-Objective Optimization of Energy Consumption and Surface Quality in Nanofluid SQCL Assisted Face Milling

Energies, 2019
Considering the significance of improving the energy efficiency, surface quality and material removal quantity of machining processes, the present study is conducted in the form of an experimental investigation and a multi-objective optimization.
Aqib Mashood Khan, Muhammad Jamil, Konstantinos Salonitis, Shoaib Sarfraz, Wei Zhao, Ning He, Mozammel Mia, GuoLong Zhao   +7 more
doaj   +1 more source

Multi-Objective Optimization of Machining Parameters for Multi-Pass CNC Turning to Minimize Carbon Emissions, Energy, Noise and Cost

Jurnal Teknik Industri, 2021
Global warming is a huge environmental issue today. This is due to the high level of world carbon emissions. The manufacturing process accounts for 30% of the world's carbon emissions production.
Bening Maulina Fittamami, Eko Pujiyanto, Yusuf Priyandari   +2 more
doaj   +1 more source