Results 51 to 60 of about 2,800 (262)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Mathematical Model of the Cutting Force while Turning AISI 5140 Steel with P20 Carbide Inserts

Журнал інженерних наук
This article deals with the prediction of the main component of cutting force during turning operations. Currently, cutting force modeling is predominantly based on experimental data and is therefore largely empirical.
Stanislav Shvets, Vitalii Kolesnyk, Ivan Dehtiarov, Roman Shvets, Vladimír Šimna, Andrii Dovhopolov, Yurii Nekrasov, Bohdan Medvediev   +7 more
doaj   +1 more source

Multi-Objective Optimization of Machining Parameters for Multi-Pass CNC Turning to Minimize Carbon Emissions, Energy, Noise and Cost

Jurnal Teknik Industri, 2021
Global warming is a huge environmental issue today. This is due to the high level of world carbon emissions. The manufacturing process accounts for 30% of the world's carbon emissions production.
Bening Maulina Fittamami, Eko Pujiyanto, Yusuf Priyandari   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sustainability Assessment during Machining Ti-6Al-4V with Nano-Additives-Based Minimum Quantity Lubrication

Journal of Manufacturing and Materials Processing, 2019
The implementation of sustainable machining process can be accomplished by different strategies including process optimization and selection of the proper lubrication techniques and cutting conditions.
Hossam A. Kishawy, Hussien Hegab, Ibrahim Deiab, Abdelkrem Eltaggaz   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Advanced Optimization of Drilling Parameters in Composite Materials: A Topsis-Based Approach for Enhanced Manufacturing Precision

Journal of Natural Fibers
Drilling natural fiber composite materials is challenging due to their anisotropic and heterogeneous structure, which often leads to delamination, thermal damage, and poor surface finish. The key objective of this study is to optimize drilling parameters
Mustapha Arslane, Mohamed Slamani, Abdelmalek Elhadi, Salah Amroune, Ugur Köklü, Madani Grine, Borhen Louhichi, Sabbah Ataya   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source