Results 101 to 110 of about 11,789,288 (234)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

HOW DO R&D INVESTMENTS MATTER FOR FINANCIAL AND SUSTAINABLE PERFORMANCE?

Фінансово-кредитна діяльність: проблеми теорії та практики
The paper aims to analyze whether R&D investments affect the financial and sustainable performance of innovative companies. For the regression analysis of the impact of R&D investments on financial and sustainable indicators, two types of models were ...
Ján Užík, Serhii Lehenchuk, Nina Poyda-Nosyk, Tetiana Ostapchuk, Tetiana Tsalko, Svitlana Nevmerzhytska   +5 more
doaj   +1 more source

Sustainability Performance Reporting

Sustainability
Sustainability reporting is an essential tool for companies and organizations to assess and communicate their sustainability performance. Its importance derives from the need for transparency and accountability to stakeholders, including investors, customers, employees and local communities.
Teodora Maria Rusu, Antonia Odagiu, Horia Pop, Laura Paulette   +3 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Integrating Enterprise Risk Management (ERM) and Environmental, Social, and Governance (ESG) Risks into Balanced Scorecard (BSC) for Sustainable Performance in a Rural Bank

Binus Business Review
The research explored how integrating Enterprise Risk Management (ERM) based on ISO 31000 with Environmental, Social, and Governance (ESG) risk considerations into a Balanced Scorecard (BSC) framework could enhance sustainable financial performance in ...
Ni Putu Gita Rahmaniati, Perminas Pangeran   +1 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Forging an energy policy for sustainable development

, 2012
Submission of the Sustainable Development Commission to the Performance and Innovation Unit of the Cabinet Office for its Energy Policy Review.Publisher ...
Sustainable Development Commission
core   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

From Gendered Entrepreneurial Cognition to Sustainable Performance: The Power of Women’s Entrepreneurial Capital in Emerging Economies

Administrative Sciences
Gender equality and sustainability remain critical global agendas emphasized in the United Nations Sustainable Development Goals (SDGs) adopted in 2015.
Thamrin Tahir, Muhammad Hasan, Muhammad Ilyas Thamrin Tahir, Andi Tenri Ampa, Andi Caezar To Tadampali, Ratnah Suharto, Muhammad Ihsan Said Ahmad   +6 more
doaj   +1 more source