Results 91 to 100 of about 10,577,795 (233)

HOW DO R&D INVESTMENTS MATTER FOR FINANCIAL AND SUSTAINABLE PERFORMANCE?

Фінансово-кредитна діяльність: проблеми теорії та практики
The paper aims to analyze whether R&D investments affect the financial and sustainable performance of innovative companies. For the regression analysis of the impact of R&D investments on financial and sustainable indicators, two types of models were ...
Ján Užík, Serhii Lehenchuk, Nina Poyda-Nosyk, Tetiana Ostapchuk, Tetiana Tsalko, Svitlana Nevmerzhytska   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Integrating Enterprise Risk Management (ERM) and Environmental, Social, and Governance (ESG) Risks into Balanced Scorecard (BSC) for Sustainable Performance in a Rural Bank

Binus Business Review
The research explored how integrating Enterprise Risk Management (ERM) based on ISO 31000 with Environmental, Social, and Governance (ESG) risk considerations into a Balanced Scorecard (BSC) framework could enhance sustainable financial performance in ...
Ni Putu Gita Rahmaniati, Perminas Pangeran   +1 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

From Gendered Entrepreneurial Cognition to Sustainable Performance: The Power of Women’s Entrepreneurial Capital in Emerging Economies

Administrative Sciences
Gender equality and sustainability remain critical global agendas emphasized in the United Nations Sustainable Development Goals (SDGs) adopted in 2015.
Thamrin Tahir, Muhammad Hasan, Muhammad Ilyas Thamrin Tahir, Andi Tenri Ampa, Andi Caezar To Tadampali, Ratnah Suharto, Muhammad Ihsan Said Ahmad   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Collaboration for Innovation and Sustainable Performance: Evidence of Relationship in Electro-Electronic Industry

BBR: Brazilian Business Review, 2016
This study aimed to identify how collaboration for innovation relates to the sustainable performance of the electronics industry in Brazil. We used a quantitative approach, collecting data by means of a cross-sectional survey in a sample of 112 companies.
Marcos Roberto Kuhl, João Carlos da Cunha, Marlete Beatriz Maçaneiro, Sieglinde Kindl da Cunha   +3 more
doaj