Results 141 to 150 of about 3,416,456 (335)

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

Providing organic school food for youths in Europe - Policy strategies, certification and supply chain management in Denmark, Finland, Italy and Norway [PDF]

, 2009
In the proceedings of an iPOPY seminar, some results of the research project were presented. First of all, Anne-Kristin Løes and Benjamin Nölting give an overview of the iPOPY project and its first results.

core  

Radical‐Mediated, Substrate‐Independent Fabrication of Hybrid Solid–Hydrogel Materials With Tunable Crosslinking: An Initiator‐ and Crosslinker‐Free Approach

Advanced Science, EarlyView.
This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Ghazal Shineh, Azin Khodaei, Pardis Keikhosravani, Masoud Zhianmanesh, Yiyun Xia, Aaron Glimour, Sina Naficy, Andrea Guzina, Daniella Bianchi, Khoon s Lim, Fariba Dehghani, Saber Amin Yavari, Marcela Bilek, Giselle C. Yeo, Behnam Akhavan   +14 more
wiley   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Development of prediction model for information technology equipment procurement as the basis of knowledge for an Intelligent Decision Support System based on carbon emissions and End-of-Life phase

Resources, Environment and Sustainability
The high quality of Information Technology (IT) equipment undoubtedly contributes to the seamless functioning of various industries in today’s digital era. As organizations strive to increase their IT equipment procurement, there is growing concern about
Nur Ulfa Maulidevi, Vhydie G. Christianto, Erna Hikmawati, Kridanto Surendro   +3 more
doaj   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Piezo‐Phototronic PVDF/HfO2/Nano‐Cu Heterostructured Thin Film for Flexible Self‐Powered Multimodal Sensing

Advanced Science, EarlyView.
Electrospinning a composite of PVDF, HfO2, and nano‐Cu transforms the discrete precursors into a continuous nanofiber mesh, forming a multi‐interface heterostructure with embedded nanoparticles. The presence of HfO2 and nano‐Cu at the fiber interfaces induces a highly aligned β‐phase, which enhances piezoelectric crystallinity and improves the material'
Jiawei Gu, Qiongle Peng, Xuanqi Zhong, Yi Zheng, Zhiqiang Ma, Xiaoxian Song, Ruihuan Zhang, Bao Liu, Yanhu Zhang, Zhengbao Yang   +9 more
wiley   +1 more source

Enhancing sustainability of medical devices procurement in Low- and Middle-Income Countries

International Journal of Sustainable Engineering
this research originates from the observation that a significant proportion of Medical Devices (MDs) in Low- and Middle-Income Countries (LMICs) remain unused.
Valerio Di Virgilio, Maria Sol Maldonado, Alexia Bouchard Saindon, Laura Astolfi   +3 more
doaj   +1 more source

Alternatives to PPPs: positive action for in-house services [PDF]

, 2008
The paper reviews empirical examples of policies and approaches for developing public services through public sector provision and direct employment, in the context of EU ...
Hall, David
core  

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source