Results 141 to 150 of about 4,740,554 (399)

Cycle tourism development in the Peak District National Park, United Kingdom [PDF]

open access: yes, 2015
Protected areas are at the centre of nature-based tourism, which is increasingly popular across the world. As visitor numbers increase, so does awareness of the harmful effects that large crowds may have on both natural resources and individuals ...
Davies, Nicholas James   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

open access: yesMolecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

The strategy implementing IoT-based land transportation for sustainable transportation

open access: yesJurnal Ilmiah Kursor: Menuju Solusi Teknologi Informasi
The development carried out by the government requires the availability of infrastructure including transportation infrastructure. Today's transportation sector planning is greatly influenced by technological advances.
Maudhy Satyadharma   +2 more
doaj   +1 more source

Greening Supply Chains: Impact on Cost and Design [PDF]

open access: yes
The consideration of environmental issues has emerged as a topic of critical importance for today’s globalized supply chains. The purpose of this paper is to develop a strategic-tactical decision-support methodology to assist managers in evaluating the
Dekker, R., Mallidis, I., Vlachos, D.
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Composite low-carbon biopolymer-amended bentonite in geosynthetic clay liners for containing acid mine drainage leachate

open access: yesJournal of Rock Mechanics and Geotechnical Engineering
Acid mine drainage (AMD) leachate is a global pollutant issue that impacts groundwater environment quality. This study investigated the feasibility of a composite biopolymer-amended bentonite as a geosynthetic clay liner core material to contain AMD ...
Heng Zhuang   +4 more
doaj   +1 more source

Urban sustainability and community development: Creating healthy sustainable urban communities [PDF]

open access: yes
Increased urbanization has also led to many challenges for urban residents. In the United States, land use and zoning, transportation and infrastructure, lack of affordable housing, and disinvestment have severely affected the quality of life of poor ...
Malo André Hutson
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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