Results 121 to 130 of about 123,234 (304)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Microtransit is a new, technology-enabled, on-demand transportation mode in which small shuttles provide shared rides through flexible routing and scheduling in response to customers\u2019 requests for rides.
National Center for Sustainable Transportation (NCST) +2 more
core +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
We Can Get There From Here: New Perspectives on Transportation Equity [Policy Brief]
This policy brief summarizes findings from the white paper that assesses academic research and transportation planning practice to provide a shared understanding of the definitions, challenges, and opportunities in this field, thereby enabling often ...
Karner, Alex A. +3 more
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Incorporating Long-Distance Travel into Transportation Planning in the United States [Presentation]
Presentation describing white paper, Incorporating Long-Distance Travel into Transportation Planning in the United States, findings. The white paper suggests utilizing a common framework for long-distance data collection and tabulation that re-defines ...
University of Vermont. Transportation Research Center +4 more
core
Bikeshare programs are increasingly popular in the United States, and they are an important part of sustainable transportation systems. They offer an alternative mode choice for many types of last-mile trips.
National Center for Sustainable Transportation (NCST) +3 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Sustainable Transport and ‘Factor Four’ [PDF]
, 2001 Veen-Groot, Danielle van, Nijkamp, Peter
openaire +3 more sources
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source