Results 131 to 140 of about 4,740,554 (399)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Users’ Perception of Private Park and Ride Facilities in Cawang Area, Jakarta, Indonesia

open access: yesJurnal Teknik Sipil, 2019
Despite various measures implemented to manage road traffic, Jakarta City is still experiencing severe congestion. The concept, as well as the implementation of integrated urban transportation strategy, is gaining more attention in public discourse and ...
Harun al-Rasyid Lubis   +2 more
doaj  

The road to sustainable transportation

open access: yesEPJ Web of Conferences, 2017
Since most modes of transportation rely on liquid energy carriers like gasoline or diesel, the approaching end of the fossil fuel era poses a special challenge. One should bear in mind that nothing matches the energy density of liquid fuels.
Hermans Jo
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Screening and evaluation of biomass upgrading strategies for sustainable transportation fuel production with biomass-derived volatile fatty acids. [PDF]

open access: yesiScience, 2022
Miller JH   +15 more
europepmc   +1 more source

An investigation of the needs and the design of an orbiting space station with growth capabilities [PDF]

open access: yes
An architectural approach to the evolutionary growth of an orbiting space station from a small manned satellite to a fully independent, self-sustainable space colony facility is presented.
Dossey, J. R., Trotti, G.
core   +1 more source

Promoting the Concept of Sustainable Transportation within the Federal System - The Need to Reinvent the U.S. DOT [PDF]

open access: yes, 2006
This paper argues that a major obstacle to progress towards sustainable development/transportation is the lack of an integrated approach to decision-making within the U.S. federal system. To address this problem, the concept of sustainable transportation
Hall, Ralph P., Sussman, Joseph M.
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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