Results 101 to 110 of about 3,864,837 (295)

Table_1_Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder.docx [PDF]

, 2018
Background: Previous studies have indicated the resting-state default mode network (DMN) related connectivity serving as predictor of sustained attention performance in healthy people.
Jie Fan (258204), Xiongzhao Zhu (303999), Jun Gan (848492), Chan, RCK, Wanting Liu (2917691), Changlian Tan, Liu, W, Liu, Wanting, Haiyan Liao, Tan, C, Wanting Liu, Gan, J, Haiyan Liao (6100043), Raymond C. K. Chan (150851), Changlian Tan (151194), Gan, Jun, Hongchun Zhang, Zhu, X, Liao, Haiyan, Mingtian Zhong (507850), Fan, Jie, Jie Fan, Chan, Raymond C. K., Jun Gan, Zhong, M, Xiongzhao Zhu, Yi, Jinyao, Jinyao Yi (304003), Jinyao Yi, Yi, J, Hongchun Zhang (6100046), Mingtian Zhong, Zhong, Mingtian, Zhu, Xiongzhao, Liao, H, Tan, Changlian, Zhang, H, Zhang, Hongchun, Raymond C. K. Chan, Fan, J   +39 more
core   +1 more source

Sustained attention and prediction: distinct brain maturation trajectories during adolescence.

Frontiers in Human Neuroscience, 2015
Adolescence is a key period for frontal cortex maturation necessary for the development of cognitive ability. Sustained attention and prediction are cognitive functions critical for optimizing sensory processing, and essential to efficiently adapt ...
Alix eThillay, Sylvie eRoux, Valérie eGissot, Isabelle eCarteau-Martin, Robert T Knight, Frédérique eBonnet-Brilhault, Frédérique eBonnet-Brilhault, Aurélie eBidet-Caulet   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Visual attention with implications for unilateral spatial neglect. [PDF]

, 1992
Recent models of visual attention (eg. Rizzolatti et al., 1987) have suggested that a similar system orients visual attention as is used to produce a saccadic eye movement. This thesis provides further support for the link between the attentional and eye
Walker, R, Walker, Robin
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Vocabulary retention, sustained attention, and enjoyment: Using Tick8 method to promote language achievement

Australian Journal of Applied Linguistics
Although language skills have gained unparalleled momentum in language education, there is a paucity of research on one of the most significant subskills, vocabulary.
Safoura Jahedizadeh, Abbas Khademorreza, Somaye Sarvari   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source