Alcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy.
Key Points Question Is alcohol use associated with achieving a sustained virologic response (SVR) when treating hepatitis C virus (HCV) infection with direct-acting antiviral (DAA) therapy?
Cartwright EJ +10 more
europepmc +2 more sources
Positive predictive value of sustained virologic response 4 weeks posttreatment for achieving sustained virologic response 12 weeks posttreatment in patients receiving glecaprevir/pibrentasvir in Phase 2 and 3 clinical trials. [PDF]
Sustained virologic response at posttreatment Week 12 (SVR12) is the widely accepted efficacy endpoint for direct‐acting antiviral agents. Those with hepatitis C virus (HCV) are presenting younger with milder liver disease, potentially reducing need for ...
Gane E +9 more
europepmc +2 more sources
Augmentation of hepatitis C virus‐specific immunity and sustained virologic response [PDF]
SummaryTreatment for chronic hepatitis C virus (HCV) infection has rapidly evolved into interferon‐free directly acting antiviral regimens (DAA) that result in high sustained virologic response. DAAs primarily work by suppressing HCV replication and rely less on the immune system than interferon‐based therapies.
Shikha Shrivastava +6 more
semanticscholar +4 more sources
Characteristics and Prognosis of De Novo Hepatocellular Carcinoma After Sustained Virologic Response. [PDF]
Hepatocellular carcinoma (HCC) can de novo develop in patients with chronic hepatitis C even after the achievement of sustained virologic response (SVR).
Toyoda H +22 more
europepmc +2 more sources
Development and surveillance of hepatocellular carcinoma in patients with sustained virologic response after antiviral therapy for chronic hepatitis C [PDF]
Hepatitis C virus (HCV) infection is a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC), and is a leading cause of liver-related deaths worldwide. Recently available direct-acting antiviral agent is very safe and highly effective (
Seong Kyun Na, Byung-Cheol Song
doaj +2 more sources
Modern pharmacotherapy of chronic hepatitis C in patients who failed to achieve sustained virologic response [PDF]
Introduction. According to WHO experts, about 150 million people suffer from chronic viral hepatitis C (CHC), and 350,000 die annually as a result of liver damage by the hepatitis C virus (HCV).
Kireyev, I.V., Zhabotynska, N.V.
doaj +3 more sources
Background and objectives: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis.
Nelson Cheinquer +3 more
doaj +2 more sources
High sustained virologic response rates, regardless of race or socioeconomic class, in patients treated with chronic hepatitis C in community practice using a specialized pharmacy team. [PDF]
Kuwelker S +21 more
europepmc +2 more sources
ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-Experienced Patients With HCV Genotype 1b Infection [PDF]
BACKGROUND & AIMS The interferon-free regimen of ABT-450 (a protease inhibitor), ritonavir, ombitasvir (an NS5A inhibitor), dasabuvir (a non-nucleoside polymerase inhibitor), and ribavirin has shown efficacy in patients with hepatitis C virus (HCV ...
Pietro Andreoné +13 more
openalex +2 more sources
Hepatitis C reinfection in patients with sustained virologic response at a national hospital in Peru, 2024. [PDF]
Zambrano-Huailla R +4 more
europepmc +3 more sources

