Results 171 to 180 of about 61,045 (270)

RNAi‐based functional genomics tools for the beet leafhopper using microinjection and nanoparticle‐based topical spray

open access: yesInsect Science, EarlyView.
• First demonstration of functional RNAi in the beet leafhopper, Neoaliturus tenellus, using both dsRNA microinjection and star polycation nanoparticle‐mediated topical spray delivery.•Microinjection achieved over 90% knockdown of Gus and Pum3, revealing gene‐specific fitness effects on survival and fecundity in beet leafhopper.•Nanoparticle‐mediated ...
Jinlong Han   +8 more
wiley   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

open access: yesIntegrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang   +6 more
wiley   +1 more source

Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress

open access: yesIntegrative Zoology, EarlyView.
Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu   +5 more
wiley   +1 more source

The Influence of Parenting Style on Neurocognitive Development of Children With an Extra X or Y Chromosome: A Prospective 1‐Year Follow‐Up Study

open access: yesAndrology, EarlyView.
ABSTRACT Background As sex chromosome trisomies (SCTs), including 47, XXX, 47, XXY, and 47, XYY, are associated with increased risk for neurodevelopmental challenges, studying SCTs may help in understanding the role of early parental caregiving in shaping neurodevelopmental phenotypes of this genetically at‐risk population.
Sophie van Rijn   +4 more
wiley   +1 more source

Mock Circulatory Loop With Autoregulated Renal Circulation Based on Perfusion Pressure for Circulatory Support Devices Evaluation

open access: yesArtificial Organs, EarlyView.
Renal autoregulation based on perfusion pressure, defined as the difference between mean arterial pressure and central venous pressure, was successfully implemented in a mock circulatory loop. This provides a platform to assess cardiovascular devices and therapies that may affect both pressures differently, such as ECMO support and intravenous fluid ...
Eden Kharrouba   +5 more
wiley   +1 more source

Predicting adolescent conduct problems: A machine learning approach using early family and child predictors

open access: yesBritish Journal of Developmental Psychology, EarlyView.
Abstract Early recognition of predictors of adolescents' conduct problems is crucial for timely intervention. The use of traditional regression models, however, is limited in the ability to identify non‐linear relationships between predictor variables. This study employed multiple machine learning algorithms to predict adolescent conduct problems from ...
Reyhaneh S. Razavi   +2 more
wiley   +1 more source

Critical-Network Lesion-Symptom Mapping. [PDF]

open access: yesHum Brain Mapp
Walker GM   +6 more
europepmc   +1 more source

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

open access: yesBritish Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco   +8 more
wiley   +1 more source

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