Results 1 to 10 of about 44 (44)

Multi-Analytical Framework to Assess the In Vitro Swallowability of Solid Oral Dosage Forms Targeting Patient Acceptability and Adherence

Pharmaceutics, 2021
A lack of effective intervention in addressing patient non-adherence and the acceptability of solid oral dosage forms combined with the clinical consequences of swallowing problems in an ageing world population highlight the need for developing methods ...
Abdul Latif Ershad, Ali Rajabi-Siahboomi, Shahrzad Missaghi, Daniel Kirby, Afzal Rahman Mohammed   +4 more
doaj   +1 more source

Palatability and Swallowability of Pimavanserin When Mixed with Selected Food Vehicles: An Exploratory Open-Label Crossover Study

Geriatrics, 2021
Dysphagia (difficulty swallowing) affects up to 13% of persons 65 years and older and 51% of older persons in nursing homes and can contribute to reduced adherence to oral medications.
Mark Forman, Alex Kouassi, Teresa Brandt, Lee Barsky, Cynthia Zamora, Daryl Dekarske   +5 more
doaj   +1 more source

Acceptability, Swallowability, Palatability, and Safety of Multiple Film-Coated Mini-Tablets in Children Aged ≥2–<7 Years: Results of an Open-Label Randomised Study

Pharmaceutics, 2023
This single-centre, open-label, randomised, parallel-group study assessed the acceptability, swallowability, palatability, and safety of film-coated, 3 mm diameter mini-tablets in children aged ≥2–
Juliane Münch, Carolin Kloft, Madhi Farhan, Vladislav Fishman, Sining Leng, Hans Martin Bosse, Viviane Klingmann   +6 more
doaj   +1 more source

Impact of Tablet Size and Shape on the Swallowability in Older Adults

Pharmaceutics, 2023
Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug ...
Henriette Hummler, Cordula Stillhart, Lisa Meilicke, Michael Grimm, Elischa Krause, Marwan Mannaa, Maik Gollasch, Werner Weitschies, Susanne Page   +8 more
doaj   +1 more source

Influence of Solid Oral Dosage Form Characteristics on Swallowability, Visual Perception, and Handling in Older Adults

Pharmaceutics, 2023
Swallowability, visual perception, and any handling to be conducted prior to use are all influence factors on the acceptability of an oral dosage form by the patient.
Henriette Hummler, Susanne Page, Cordula Stillhart, Lisa Meilicke, Michael Grimm, Marwan Mannaa, Maik Gollasch, Werner Weitschies   +7 more
doaj   +1 more source

Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People

Pharmaceutics, 2022
3D printing (3DP) has been proposed as a novel approach for personalising dosage forms for children and young people (CYP). Owing to its low cost and the lack of need for finishing steps, fused deposing modelling (FDM) 3DP has been heavily researched in ...
Louise Bracken, Rober Habashy, Emma McDonough, Fiona Wilson, Joanne Shakeshaft, Udeme Ohia, Tamar Garcia-Sorribes, Abdullah Isreb, Mohamed A. Alhnan, Matthew Peak   +9 more
doaj   +1 more source

Evaluating the Acceptability, Swallowability, and Palatability of Film-Coated Mini-Tablet Formulation in Young Children: Results from an Open-Label, Single-Dose, Cross-Over Study

Pharmaceutics, 2023
Mini-tablets are advantageous over liquid formulations in overcoming challenges related to stability, taste, and dosage. This open-label, single-dose, cross-over study investigated the acceptability and safety of drug-free, film-coated mini-tablets in ...
Juliane Münch, Isabelle Sessler, Hans Martin Bosse, Manfred Wargenau, Janine D. Dreesen, Giulio Loforese, Nicholas J. A. Webb, Rama Sivasubramanian, Sibylle Reidemeister, Philipp Lustenberger, Viviane Klingmann   +10 more
doaj   +1 more source

Preference, Perception, and Acceptability of Fluid Gels as a Potential Age-Appropriate Dosage Form for Elderly Patients with Dysphagia

Gels, 2022
The development of pharmaceutical dosage forms that are tailored to specific populations according to their preferences and acceptability could improve medication adherence, which could lead to effective pharmacotherapy.
Zul Hadif Abd Aziz, Haliza Katas, Marhanis Salihah Omar, Noraida Mohamed Shah, Salma Mohamad Yusop, Mohamad Nasir Shafiee, Siti Fatimah Mohd Tarmizi   +6 more
doaj   +1 more source

Medicines Acceptability in Hospitalized Children: An Ongoing Need for Age-Appropriate Formulations

Pharmaceutics, 2020
Although knowledge on medicine acceptability remains fragmented, this multi-faceted concept has emerged as a key factor for compliance in pediatrics. In order to investigate the acceptability of medicines used in the University Medical Centre Ibn Sina ...
Thibault Vallet, Omar Elhamdaoui, Amina Berraho, Lalla Ouafae Cherkaoui, Yamna Kriouile, Chafiq Mahraoui, Nezha Mouane, Anne-Marie Pense-Lheritier, Fabrice Ruiz, Yahya Bensouda   +9 more
doaj   +1 more source

Practical Recommendations for the Manipulation of Kinase Inhibitor Formulations to Age-Appropriate Dosage Forms

Pharmaceutics, 2022
Over 75 kinase inhibitors (KIs) have been approved for the treatment of various cancers. KIs are orally administrated but mostly lack pediatric age-appropriate dosage forms or instructions for dose manipulation.
Emma C. Bernsen, Valery J. Hogenes, Bastiaan Nuijen, Lidwien M. Hanff, Alwin D. R. Huitema, Meta H. M. Diekstra   +5 more
doaj   +1 more source