Impact of Tablet Size and Shape on the Swallowability in Older Adults [PDF]
Pharmaceutics, 2023 Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug ...
Michael Grimm +2 more
exaly +4 more sources
Evaluating the Acceptability, Swallowability, and Palatability of Film-Coated Mini-Tablet Formulation in Young Children: Results from an Open-Label, Single-Dose, Cross-Over Study [PDF]
Pharmaceutics, 2023 Mini-tablets are advantageous over liquid formulations in overcoming challenges related to stability, taste, and dosage. This open-label, single-dose, cross-over study investigated the acceptability and safety of drug-free, film-coated mini-tablets in ...
Viviane Klingmann +2 more
exaly +4 more sources
Influence of Solid Oral Dosage Form Characteristics on Swallowability, Visual Perception, and Handling in Older Adults [PDF]
Pharmaceutics, 2023 Swallowability, visual perception, and any handling to be conducted prior to use are all influence factors on the acceptability of an oral dosage form by the patient.
Michael Grimm +2 more
exaly +4 more sources
Multi-Analytical Framework to Assess the In Vitro Swallowability of Solid Oral Dosage Forms Targeting Patient Acceptability and Adherence [PDF]
Pharmaceutics, 2021 A lack of effective intervention in addressing patient non-adherence and the acceptability of solid oral dosage forms combined with the clinical consequences of swallowing problems in an ageing world population highlight the need for developing methods ...
Abdul Ershad +2 more
exaly +4 more sources
Palatability and Swallowability of Pimavanserin When Mixed with Selected Food Vehicles: An Exploratory Open-Label Crossover Study [PDF]
Geriatrics (Switzerland), 2021 Dysphagia (difficulty swallowing) affects up to 13% of persons 65 years and older and 51% of older persons in nursing homes and can contribute to reduced adherence to oral medications.
Daryl Dekarske
exaly +4 more sources
Swallowability of Minitablets among Children Aged 6–23 Months: An Exploratory, Randomized Crossover Study [PDF]
Pharmaceutics, 2022 Minitablets have garnered interest as a new paediatric formulation that is easier to swallow than liquid formulations. In Japan, besides the latter, fine granules are frequently used for children.
Tsutomu Harada +2 more
exaly +4 more sources
Acceptability, Swallowability, Palatability, and Safety of Multiple Film-Coated Mini-Tablets in Children Aged ≥2–<7 Years: Results of an Open-Label Randomised Study [PDF]
Pharmaceutics, 2023 This single-centre, open-label, randomised, parallel-group study assessed the acceptability, swallowability, palatability, and safety of film-coated, 3 mm diameter mini-tablets in children aged ≥2–
Juliane Münch +6 more
doaj +2 more sources
Young patients’ involvement in a composite endpoint method development on acceptability for paediatric oral dosage forms [PDF]
Research Involvement and Engagement, 2023 Background In line with the European Paediatric Regulation, the European Medicines Agency (EMA) asks for investigation of a medicine’s acceptability in paediatric medicines development. A standardised acceptability testing method combining the outcome of
Sibylle Reidemeister +5 more
doaj +2 more sources
Acceptability of minitablets in soft food. A randomised cross-over study in children [PDF]
Frontiers in PharmacologyObjectiveTo evaluate the acceptability of placebo minitablets mixed with different volumes of soft food in children aged 6 months to 7 years.MethodsIn this UK hospital-based, randomised cross-over study, children received placebo minitablets in yoghurt ...
Jennifer C. Duncan +13 more
doaj +2 more sources
A Randomized, Open, Single-Administration, Cross-Over Study to Investigate the Acceptability, Swallowability, Palatability, and Preference of Different Oral Placebo Formulations in Patients with Multiple Sclerosis [PDF]
PharmaceuticsBackground: There is a paucity of systematic investigations of the acceptability and preference of alternative oral drug formulations in multiple sclerosis (MS) patients. The use of appropriate oral dosage forms has the potential to circumvent challenges
Hans Martin Bosse +13 more
doaj +2 more sources