Swallowability of Minitablets among Children Aged 6–23 Months: An Exploratory, Randomized Crossover Study [PDF]
Pharmaceutics, 2022 Minitablets have garnered interest as a new paediatric formulation that is easier to swallow than liquid formulations. In Japan, besides the latter, fine granules are frequently used for children.
Nao Mitsui +11 more
doaj +5 more sources
Young patients’ involvement in a composite endpoint method development on acceptability for paediatric oral dosage forms [PDF]
Research Involvement and Engagement, 2023 Background In line with the European Paediatric Regulation, the European Medicines Agency (EMA) asks for investigation of a medicine’s acceptability in paediatric medicines development. A standardised acceptability testing method combining the outcome of
Sibylle Reidemeister +5 more
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Patient-Centric Medicine Design: Key Characteristics of Oral Solid Dosage Forms that Improve Adherence and Acceptance in Older People [PDF]
Pharmaceutics, 2020 Older people represent a very heterogeneous patient population and are the major user group of medication. Age-related changes mean that this population can encounter barriers towards taking medicines orally.
Zakia Shariff +4 more
doaj +3 more sources
Validating a composite endpoint for acceptability evaluation of oral drug formulations in the pediatric population: a randomized, open-label, single dose, cross-over study [PDF]
Frontiers in PharmacologyObjectiveThis study aimed to validate the newly developed composite acceptability endpoint to investigate acceptability of oral pediatric drug formulations that integrates swallowability and palatability assessments.MethodsIn this open-label study ...
Juliane Münch +7 more
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3D-printed rice cake for dysphagia diet: Effect of rice flour/κ-carrageenan/curdlan complex gel on structure, swallowability, and storage [PDF]
Future FoodsRice cakes are a traditional rice-based dessert consumed in Asian countries. They are an excellent source of carbohydrates and can be used as a staple food. However, they have a hard and gummy texture.
Jiyoon Kim +2 more
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Rectal Bioavailability of Amoxicillin from Hollow-Type Suppositories: Effect of Chemical Form of Amoxicillin [PDF]
Pharmaceutics, 2023 Rectal drug administration could offer advantages in the delivery of medicines for children by avoiding swallowability issues, improving stability and enabling administration by caregivers.
Trusha J. Purohit +3 more
doaj +2 more sources
Acceptability in the Older Population: The Importance of an Appropriate Tablet Size [PDF]
Pharmaceutics, 2020 Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics of patients. Commonly, patients with dysphagia (swallowing disorders) experience
Thibault Vallet +10 more
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Patient Acceptability and Preferences for Solid Oral Dosage Form Drug Product Attributes: A Scoping Review [PDF]
Patient Preference and AdherenceBrett Hauber,1 Mark V Hand,2 Bruno C Hancock,3 Joseph Zarrella,3 Ljiljana Harding,4 Michaela Ogden-Barker,5 Amy S Antipas,3 Stephen J Watt1 1Pfizer Inc, New York, NY, USA; 2Pfizer Ireland Pharmaceuticals, Ballintaggart, Cork, Ringaskiddy, Ireland ...
Hauber B +7 more
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Real-World Evidence of 3D Printing of Personalised Paediatric Medicines and Evaluating Its Potential in Children with Cancer: A Scoping Review [PDF]
PharmaceuticsPersonalised medicine, facilitated by advancements like 3D printing, may offer promise in oncology. This scoping review aims to explore the applicability of 3D printing for personalised pharmaceutical dosage forms in paediatric cancer care, focusing on ...
Munsur Ahmed +3 more
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Formulation and characterisation of protein-rich custard-like soft food intended for the elderly with swallowing difficulties [PDF]
Future FoodsSwallowing problem is prevalent in the elderly which requires high intake of protein through soft foods. This study developed protein-rich custard-type soft foods for elderly with dysphagia and evaluated the impact of milk protein content (3.9 % to 8.9 %)
Yuxin Qin +3 more
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