Results 41 to 50 of about 1,510,443 (341)

Screening variability and change of soil moisture under wide-ranging climate conditions : Snow dynamics effects [PDF]

, 2015
Acknowledgments This work has been supported by the Stockholm University strategic environmental research program Ekoklim and The Swedish Research Council Formas (project 2012-790).Peer reviewedPublisher ...
Destouni, Georgia, Verrot, Lucile
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

What made Proto-Germanic *jah ‘and’ an infinitive marker in westernmost Uralic? Observations from the Saami-Scandinavian border

Norsk Lingvistisk Tidsskrift, 2017
The paper provides an account of a previously neglected infinitive marker in South Saami. Originally recognized by Bergsland (1946), later descriptions of South Saami have disregarded the use of the coordinating conjunction jih ‘and’ as what appears to ...
Jussi Ylikoski
doaj  

Creating a Historical Migration Dataset from Finnish Church Records, 1800–1920

Journal of Open Humanities Data
This article presents a large-scale effort to create a structured dataset of internal migration in Finland between 1800 and 1920 using digitized church moving records.
Ari Vesalainen, Jenna Kanerva, Aïda Nitsch, Kiia Korsu, Ilari Larkiola, Laura Ruotsalainen, Filip Ginter   +6 more
doaj   +1 more source

Does surgeon experience affect patient-reported outcomes 1 year after primary total hip arthroplasty?: A register-based study of 6,713 cases in western Sweden

Acta Orthopaedica, 2018
Background and purpose — Several studies have reported on the influence of various factors on patient-reported outcomes (PROs) after total hip arthroplasty (THA), but very few have focused on the experience of the surgeon. We investigated any association
Per Jolbäck, Ola Rolfson, Maziar Mohaddes, Szilárd Nemes, Johan Kärrholm, Göran Garellick, Hans Lindahl   +6 more
doaj   +1 more source

Articulation rate in Swedish child-directed speech increases as a function of the age of the child even when surprisal is controlled for [PDF]

, 2017
In earlier work, we have shown that articulation rate in Swedish child-directed speech (CDS) increases as a function of the age of the child, even when utterance length and differences in articulation rate between subjects are controlled for.
Bjerva, Johannes, Hörberg, Thomas, Sjons, Johan, Östling, Robert   +3 more
core   +4 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Low-quality employment trajectories and the risk of common mental health disorders among individuals with Swedish and foreign background – a register-based cohort study

Scandinavian Journal of Work, Environment & Health, 2022
OBJECTIVE: This study aimed to examine the effects of low-quality employment trajectories on severe common mental disorders (CMD) according to Swedish and foreign background. METHODS: In this longitudinal study based on Swedish population registries (N=2 
Roxana Pollack, Bertina Kreshpaj, Johanna Jonsson, Theo Bodin, Virginia Gunn, Cecilia Orellana, Per-Olof Östergren, Carles Muntaner, Nuria Matilla-Santander   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Implant survival and patient-reported outcome following total hip arthroplasty in patients 30 years or younger: a matched cohort study of 1,008 patients in the Swedish Hip Arthroplasty Register

Acta Orthopaedica, 2019
Background and purpose — The outcome of total hip arthroplasty (THA) in younger patients is suggested to be inferior compared with the general THA population. There is a lack of studies with long-term follow up for very young patients.
Maziar Mohaddes, Emma NaucléR, Johan Kärrholm, Henrik Malchau, Daniel Odin, Ola Rolfson   +5 more
doaj   +1 more source