Results 41 to 50 of about 260,542 (274)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Numerical analysis of the abnormal water level rise phenomenon on the west coast of Ca Mau Peninsula, Vietnam

Frontiers in Built Environment
The abnormal water level rise on the west coast of Ca Mau Peninsula, Vietnam, has dramatically increased as extreme events have intensified in recent decades. To forecast it, it is necessary to understand the mechanism.
Nguyen Ba Thuy, Pham Van Tien, Nguyen Kim Cuong, Pham Khanh Ngoc, Vu Hai Dang, Le Dinh Quyet, Sooyoul Kim, Cecilie Wettre, Lars Robert Hole   +8 more
doaj   +1 more source

Seasonal Variability of Wind Sea and Swell Waves Climate along the Canary Current: The Local Wind Effect

Journal of Marine Science and Engineering, 2018
A climatology of wind sea and swell waves along the Canary eastern boundary current area, from west Iberia to Mauritania, is presented. The study is based on the European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis ERA-Interim.
Alvaro Semedo
doaj   +1 more source

Evidence of energy and momentum flux from swell to wind [PDF]

, 2016
Author Posting. © American Meteorological Society, 2016. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 46 (
Donelan, Mark A., Drennan, William M., Kahma, Kimmo, Terray, Eugene A.   +3 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Age, Depth, and Residual Depth Anomalies in the North Pacific: Implications for Thermal Models of the Lithosphere and Upper Mantle [PDF]

, 1986
We present an empirical basement depth versus age relation for the North Pacific Ocean, based on the statistical treatment of an ocean-wide gridded data set.
Renkin, Miriam K., Sclater, John G.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A worldwide coastal analysis of the climate wave systems

Frontiers in Marine Science
Wind generated waves of a sea state are generally the result of the superposition of wind sea and swells, making the frequency-direction wave energy distribution crucial for comprehending this behavior.
Ottavio Mattia Mazzaretto, Melisa Menendez, Melisa Menendez   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Performance Assessment of ERA5 Wave Data in a Swell Dominated Region

Journal of Marine Science and Engineering, 2020
The present paper deals with a performance assessment of the ERA5 wave dataset in an ocean basin where local wind waves superimpose on swell waves. The evaluation framework relies on observed wave data collected during a coastal experimental campaign ...
Maria Francesca Bruno, Matteo Gianluca Molfetta, Vincenzo Totaro, Michele Mossa   +3 more
doaj   +1 more source