Results 51 to 60 of about 267,062 (343)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
A worldwide coastal analysis of the climate wave systems
Frontiers in Marine ScienceWind generated waves of a sea state are generally the result of the superposition of wind sea and swells, making the frequency-direction wave energy distribution crucial for comprehending this behavior.
Ottavio Mattia Mazzaretto +2 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Numerical Verification of the Weak Turbulent Model for Swell Evolution
, 2007 The purpose of this article is numerical verification of the theory of weak turbulence. We performed numerical simulation of an ensemble of nonlinearly interacting free gravity waves (swell) by two different methods: solution of primordial dynamical ...
A. Pushkarev +54 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
CT&F Ciencia, Tecnología & FuturoRecent research highlights a significant challenge in maintaining power quality in grid-connected wind energy systems. This challenge is further complicated by issues such as the lack of reactive power support and the high installation costs associated ...
Shinagam Rajshekar +2 more
doaj +1 more source
Performance Assessment of ERA5 Wave Data in a Swell Dominated Region
Journal of Marine Science and Engineering, 2020 The present paper deals with a performance assessment of the ERA5 wave dataset in an ocean basin where local wind waves superimpose on swell waves. The evaluation framework relies on observed wave data collected during a coastal experimental campaign ...
Maria Francesca Bruno +3 more
doaj +1 more source
On the Equivalence of Forward Mode Automatic Differentiation and Symbolic Differentiation
, 2020 We show that forward mode automatic differentiation and symbolic differentiation are equivalent in the sense that they both perform the same operations when computing derivatives.
Laue, Soeren
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source