Results 41 to 50 of about 47,875 (268)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A worldwide coastal analysis of the climate wave systems

Frontiers in Marine Science
Wind generated waves of a sea state are generally the result of the superposition of wind sea and swells, making the frequency-direction wave energy distribution crucial for comprehending this behavior.
Ottavio Mattia Mazzaretto, Melisa Menendez, Melisa Menendez   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Power quality enrichment in grid integrated wind energy conversion system using improvised controller based D-STATCOM

CT&F Ciencia, Tecnología & Futuro
Recent research highlights a significant challenge in maintaining power quality in grid-connected wind energy systems. This challenge is further complicated by issues such as the lack of reactive power support and the high installation costs associated ...
Shinagam Rajshekar, Lalit Chandra Saikia, Lavanya Nandyala   +2 more
doaj   +1 more source

Performance Assessment of ERA5 Wave Data in a Swell Dominated Region

Journal of Marine Science and Engineering, 2020
The present paper deals with a performance assessment of the ERA5 wave dataset in an ocean basin where local wind waves superimpose on swell waves. The evaluation framework relies on observed wave data collected during a coastal experimental campaign ...
Maria Francesca Bruno, Matteo Gianluca Molfetta, Vincenzo Totaro, Michele Mossa   +3 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Atypical Linear Tectonic Block of the Intraplate Deformation Zone in the Central Indian Ocean Basin

Journal of Marine Science and Engineering
The Central Indian Ocean Basin (CIOB) is distinguished by unusually high tectonic activity, setting it apart from all other passive oceanic basins. Within the interior of the Indo-Australian lithospheric plate lies a unique area of intraplate deformation.
Vsevolod V. Yutsis, Oleg V. Levchenko, Alexander V. Tevelev, Yulia G. Marinova, Ilia A. Veklich, Abraham Del Razo Gonzalez   +5 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source