Results 61 to 70 of about 812,721 (324)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Swimming in curved space or The Baron and the cat
, 2006 We study the swimming of non-relativistic deformable bodies in (empty) static curved spaces. We focus on the case where the ambient geometry allows for rigid body motions. In this case the swimming equations turn out to be geometric. For a small swimmer,
Besse A +11 more
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Effects of seasonal change on activity rhythms and swimming behavior of age-0 bluefish (Pomatomus saltatrix) and a description of gliding behavior [PDF]
, 2009 Daily and seasonal activity rhythms, swimming speed, and modes of swimming were studied in a school of spring-spawned age-0 bluefish (Pomatomus saltatrix) for nine months in a 121-kL research aquarium.
Stehlik, Linda L.
core
The Performance of Discrete Models of Low Reynolds Number Swimmers
, 2015 Swimming by shape changes at low Reynolds number is widely used in biology and understanding how the efficiency of movement depends on the geometric pattern of shape changes is important to understand swimming of microorganisms and in designing low ...
Othmer, Hans G., Wang, Qixuan
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Thrifty swimming with shear-thinning [PDF]
, 2018 Microscale propulsion is integral to numerous biomedical systems, for example biofilm formation and human reproduction, where the surrounding fluids comprise suspensions of polymers.
Gagnon, David A. +1 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Stochastic dynamics of active swimmers in linear flows
, 2014 Most classical work on the hydrodynamics of low-Reynolds-number swimming addresses deterministic locomotion in quiescent environments. Thermal fluctuations in fluids are known to lead to a Brownian loss of the swimming direction.
Lauga, Eric +3 more
core +1 more source