Results 91 to 100 of about 8,554,084 (253)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
How speed makes a difference : A case study of 100- meter races
, 2016 Swimming faster has always been of interest to coaches. How we perceive time and swimming speed is vital to how we train, interpret the results of training, plan for completion and evaluate performance.
Buhre, Torsten
core +1 more source
Effect of tumble turns on swimming performance in level 3 swimmers [PDF]
, 2018 Magister Artium (Sport, Recreation and Exercise Science) - MA(SRES)Swimming, as a sport, is constantly developing, both through the resources employed in training and assessment, and through the technological development of the fundamental aspects of ...
Smithdorf, Gareth
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Predicting Competitive Swimming Performance
Central European Journal of Sport Sciences and Medicine, 2015 The aim of this study was to present the results of analyses conducted by means of complementary analytic tools in order to verify their efficacy and the hypothesis that Kohonen’s neural models may be applied in the classification process of ...
Olga Fidos-Czuba +7 more
doaj
A laser-equipped chamber for the assessment of sprint swimming traits in fishes
Frontiers in Ecology and EvolutionSprint swimming performance in fishes is relatively understudied despite its critical role in predation attempts, prey evasion, spawning events, and overcoming hydraulic challenges.
Kenneth W. Zillig +9 more
doaj +1 more source