Results 101 to 110 of about 8,554,084 (253)
Proposal of a deterministic model to explain swimming performance. [PDF]
, 2013 Swimming is one of the most challenging sports to investigate. Since long, swimming practitioners base their decisions in scientific evidences. It is known that several scientific domains have a significant role in the swimming performance, such as the ...
Costa, Mário +2 more
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Variability in coach assessment of technique in front crawl sprint swimming
, 2014 Competitive swim performance is assessed by total race time and can be analysed to comprise of three components. The first is the start time, the second is the time spent free swimming and the third is the turn performance time.
Ball, Nick +3 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Diurnal variation in swim performance remains, irrespective of training once or twice daily [PDF]
, 2007 Fast swim times in morning rounds are essential to ensure qualification in evening finals. A significant time-of-day effect in swimming performance has consistently been observed, although physical activity early in the day has been postulated to reduce ...
Martin, Louise +4 more
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
FishesThe present study aimed to explore whether water flow velocity could affect the swimming ability and overall energy metabolism of wild Amur grayling (Thymallus grubii). Swimming performance was assessed by measuring critical swimming speed (Ucrit), burst
Cunhua Zhai +6 more
doaj +1 more source
Sonification of Pressure Changes in Swimming for Analysis and Optimization [PDF]
, 2012 Hermann T, Ungerechts B, Toussaint H, Grote M. Sonification of Pressure Changes in Swimming for Analysis and Optimization. Presented at the International Conference on Auditory Display (ICAD 2012), Atlanta, GA, USA.This paper introduces the sonification ...
Ungerechts, Bodo +6 more
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source