Results 31 to 40 of about 37,459 (182)

Regional Transmission and Reassortment of 2.3.4.4b Highly Pathogenic Avian Influenza (HPAI) Viruses in Bulgarian Poultry 2017/18

Viruses, 2020
Between 2017 and 2018, several farms across Bulgaria reported outbreaks of H5 highly-pathogenic avian influenza (HPAI) viruses. In this study we used genomic and traditional epidemiological analyses to trace the origin and subsequent spread of these ...
Divya Venkatesh, Adam Brouwer, Gabriela Goujgoulova, Richard Ellis, James Seekings, Ian H. Brown, Nicola S. Lewis   +6 more
doaj   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Genetic variations of nucleoprotein gene of influenza A viruses isolated from swine in Thailand

Virology Journal, 2010
Background Influenza A virus causes severe disease in both humans and animals and thus, has a considerably impact on economy and public health. In this study, the genetic variations of the nucleoprotein (NP) gene of influenza viruses recovered from swine
Thippamom Nattakarn, Sreta Donreuthai, Kitikoon Pravina, Thanawongnuwech Roongroje, Poovorawan Yong, Theamboonlers Apiradee, Suwannakarn Kamol, Parchariyanon Sujira, Damrongwatanapokin Sudarat, Amonsin Alongkorn   +9 more
doaj   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Long-Term Epidemiology and Evolution of Swine Influenza Viruses, Vietnam

Emerging Infectious Diseases, 2023
Influenza A viruses are a One Health threat because they can spill over between host populations, including among humans, swine, and birds. Surveillance of swine influenza virus in Hanoi, Vietnam, during 2013–2019 revealed gene pool enrichment from ...
Jonathan Cheung, Anh Ngoc Bui, Sonia Younas, Kimberly M. Edwards, Huy Quang Nguyen, Ngoc Thi Pham, Vuong Nghia Bui, Malik Peiris, Vijaykrishna Dhanasekaran   +8 more
doaj   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Genetic diversity and circulation of influenza A viruses in Italian pig farms: insights from surveillance and vaccination

Porcine Health Management
Background The genetic diversity of influenza A viruses in swine (IAV-S) in Europe, including key subtypes such as H1N1, H3N2, H1N2, and H1N1pdm09 (which features H1 hemagglutinin genes from the H1A, H1B, and H1C genetic clades), presents challenges for ...
Chiara Chiapponi, Alice Prosperi, Laura Soliani, Aurora De Mattia, Ada Mescoli, Camilla Torreggiani, Benedetta Cordioli, Ana Moreno, Luca Ferrari, Melania Andrani, Elena De Angelis, Valeria Cavalli, Giovanbattista Guadagnini, Davide Ponzoni, Emanuela Pileri, Matteo Ricchi, Paolo Borghetti, Paolo Martelli, Andrea Luppi   +18 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Trends in seroprevalence of influenza A virus infections in pigs in France (2008–2022)

Porcine Health Management
Background Swine influenza A viruses (swIAV) are highly contagious zoonotic pathogens that cause an acute respiratory infection in pigs, presenting substantial economic and health risks for animals and farmers.
Séverine Hervé, Nicolas Rose, Nicolas Barbier, Stéphane Quéguiner, Stéphane Gorin, Roselyne Fonseca, Gaëtan Pinsard, Gautier Richard, Agnès Jardin, Gaëlle Simon   +9 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source