Results 51 to 60 of about 4,650,677 (354)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
On Flow Reversal in Turbulent Swirling Flow
Journal of the Physical Society of Japan, 2003 Summary: A turbulent swirling flow is studied with the aid of a variational method. The mean-flow field is expressed by the mean vorticity proportional to its curl. The total axial flux and total helicity per unit length are introduced to characterize the swirling flow, and the condition for the reversal of the axial flow near the center of flow is ...
Itoh, Kimitaka +3 more
openaire +1 more source
, 2017 Results of experimental investigations of the turbulent swirl flow in three straight conical diffusers with various diffuser total angles are presented in this paper.
Dejan Ilić +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Mesh Twisting Technique for Swirl Induced Laminar Flow Used to Determine a Desired Blade Shape
Applied Sciences, 2018 Swirling flow has been shown to increase heat transfer in heat exchangers. However, producing swirl while not presenting a severe pressure drop can be a challenge.
Ásdís Helgadóttir +3 more
doaj +1 more source
Parameter optimization of longitudinal swirl nozzle based on CFD
Meikuang Anquan, 2021 In order to solve the problems of high water consumption and poor atomization effect of mine swirl nozzles, the relevant parameters that affect the spray effect are proposed: the spiral angle of the swirl core, the length ratio of the nozzle contraction
ZHANG Zepeng, PAN Yue, YANG Fan, MA Hao
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Swirl flow response to transverse and axial acoustic forcing
Journal of Fluid Science and Technology, 2014 The present study is an experimental investigation on the effect of axial and transverse acoustic forcing on a generic swirl flow. The aim is to provide a qualitative understanding of typical swirl flow response to transverse acoustic forcing, for a ...
Aditya SAURABH +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source