Results 101 to 110 of about 3,579,556 (333)

Pulse switching for high energy lasers [PDF]

open access: yes, 1981
A saturable inductor switch for compressing the width and sharpening the rise time of high voltage pulses from a relatively slow rise time, high voltage generator to an electric discharge gas laser (EDGL) also provides a capability for efficient energy ...
Laudenslager, J. B., Pacala, T. J.
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The use of antipyschotic prescription for an university psychiatry clinic: A retrospective study

open access: yesPsychiatry and Clinical Psychopharmacology, 2021
Objective: The launch of new generation antipsychotics in 1990 impacting the prescription trends all over the world. The aim of this study was to evaluate trends and patterns regarding antipsychotic prescription on inpatient and outpatient basis at a ...
Aslıhan Sayın   +3 more
doaj  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Safety and effectiveness of adalimumab in patients with moderate-to-severe psoriasis who had inadequate therapeutic response to prior etanercept

open access: yesDermatologica Sinica, 2013
Background: Few studies exist that evaluate the therapeutic response among switchers of tumor necrosis antagonists in patients with psoriasis, especially Asian patients.
Ting-Shun Wang, Tsen-Fang Tsai
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Measurement and Evaluation of Wear Frogs Switches ŽSR

open access: yesCivil and Environmental Engineering, 2014
This paper deals with the measurement and evaluation of wear frogs switches ZSR. One of the main problems is the oversize wear. The possibilities analysis of this problem is offered through a set of switches and monitoring of selected parameters.
Urda Ján   +2 more
doaj   +1 more source

A Compact Thermal Heat Switch for Cryogenic Space Applications Operating near 100 K

open access: yes, 2013
A thermal heat switch has been developed intended for cryogenic space applications operating around 100 K. The switch was designed to separate two pulse tube cold heads that cool a common focal plane array. Two cold heads are used for redundancy reasons,
Dietrich, Marc   +2 more
core   +1 more source

Poly(A)-tail profiling reveals an embryonic switch in translational control

open access: yesNature, 2014
Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded greater understanding of poly(A)-tail function. Here we describe poly(A)-tail length profiling
Alexander O. Subtelny   +4 more
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

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