Results 141 to 150 of about 3,579,556 (333)
Nauka ta progres transportu, 2011 The results of experimental research of influence of length of a direct insert between adjacent switches laid according to the first scheme on admissible speeds of movement of trains by criterion of switch strength and the strained-and-stressed state of ...
K. V. Moyseyenko
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Práctica de aplicación de seguridad y distribución de LAN corporativa
Universidad y Sociedad, 2018 La alta demanda de en una red empresarial al área de TI nos incita a la incesante búsqueda de nuevas técnicas para precautelar y proteger la información generada por una empresa.
Jorge Humberto Tapia Celi +2 more
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
Journal of Clinical Investigation, 2007 C. Lumeng, Jennifer L Bodzin, A. Saltiel
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
Cell, 1996 D. Hanahan, J. Folkman
semanticscholar +1 more source