Results 71 to 80 of about 24,274,203 (388)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Synchronization Analysis for State-Dependent Spiking Switched Neural Networks
IEEE AccessThis paper investigates the exponential synchronization problem for the proposed state-dependent spiking switched neural network. Under certain conditions, it is proven that state-dependent spiking switched systems can be transformed into fixed-time ...
Xianxiu Zhang +4 more
doaj +1 more source
Convergence Rate of Nonlinear Switched Systems
, 2015 This paper is concerned with the convergence rate of the solutions of nonlinear switched systems. We first consider a switched system which is asymptotically stable for a class of inputs but not for all inputs.
Jouan, Philippe, Naciri, Saïd
core +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
An algorithm for constructing Lyapunov functions
Electronic Journal of Differential Equations, 2007 In this monograph we develop an algorithm for constructing Lyapunov functions for arbitrary switched dynamical systems $dot{mathbf{x}} = mathbf{f}_sigma(t,mathbf{x})$, possessing a uniformly asymptotically stable equilibrium.
Sigurdur Freyr Hafstein
doaj
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Descomposición en suma de cuadrados: teoría y aplicaciones en control
Ingeniería e Investigación, 2010 Las técnicas de descomposición en sumas de cuadrados (SOS) permiten emplear métodos numéricos para probar la positividad de funciones polinómicas multivariables resolviendo problemas de programación en semidefinida. Teniendo en cuenta que generalmente es
Andrés Pantoja +2 more
doaj
On Delay Independent Stabilization Analysis for a Class of Switched Large-Scale Time-Delay Systems
Abstract and Applied Analysis, 2013 In view of the state-driven switching method, the sufficient stability conditions with delay independence will be derived for the switched large-scale time-delay systems.
Chi-Jo Wang, Juing-Shian Chiou
doaj +1 more source
On Stability of Perturbed Nonlinear Switched Systems with Adaptive Reinforcement Learning
Energies, 2020 In this paper, a tracking control approach is developed based on an adaptive reinforcement learning algorithm with a bounded cost function for perturbed nonlinear switched systems, which represent a useful framework for modelling these converters, such ...
Phuong Nam Dao +3 more
doaj +1 more source