Results 81 to 90 of about 142,668 (266)

On Switched Hamiltonan Systems

open access: yes, 2002
In this paper we study the well-posedness and stability of a class of switched linear passive systems. Instrumental in our approach is the result, also of interest in its own right, that any linear passive input-state-output system with strictly positive storage function can be written as a port-Hamiltonian system.
Gerritsen, K.M.   +2 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Anti-Disturbance Bumpless Transfer Control for a Switched Systems via a Switched Equivalent-Input-Disturbance Approach

open access: yesMathematics
This paper concentrates on the issue of anti-disturbance bumpless transfer (ADBT) control design for switched systems. The ADBT control design problem refers to designing a continuous controller and a switching rule to ensure the switched system ...
Jiawen Wu, Qian Liu, Pan Yu
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

A Stability Condition with Delay-Dependence for a Class of Switched Large-Scale Time-Delay Systems

open access: yesJournal of Applied Mathematics, 2013
By using the time-switched method and the comparison theorem, we derived a criterion of delay-dependent stability for the switched large-scale time-delay systems. To guarantee the exponential stability for the switched large-scale time-delay systems with
Chi-Jo Wang, Juing-Shian Chiou
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Dynamic Event-Triggered Output Feedback Control for Switched Systems via Switched Lyapunov Functions

open access: yesApplied Sciences
This study carries out the research on event-triggered output feedback control tailored for discrete-time switched linear systems. A dynamic event-triggered mechanism (DETM) is utilized to mitigate the triggering frequency.
Xinyue Wang, Yanhui Tong, Yuyuan Li
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Absolute stability of switched lurie systems

open access: yesApplied Mathematics in Science and Engineering
This paper investigates the absolute stability problem of switched Lurie systems. Based on two new switched time-varying Lyapunov-Lurie functions, sufficient conditions for the absolute stability of the switched Lurie systems are provided under the ...
Qiang Yu, Junzhou Li, Yanping Guo
doaj   +1 more source

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