Results 71 to 80 of about 142,668 (266)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Robust State Estimation for Uncertain Switched Fuzzy Systems with Time-Varying Delays by Average Dwell Time Approach

Majlesi Journal of Electrical Engineering
Switched systems are an important class of hybrid systems. In recent years, such systems have drawn considerable attentions in control field. A switched fuzzy system is a switching system, for which all subsystems are fuzzy systems.
Shirin Yousefizadeh, Jafar Zarei
doaj  

Event-Triggered Impulsive Control for Switched Systems Under Aperiodic Denial-of-Service Attacks

Mathematics
Ensuring input-to-state stability (ISS) of networked control systems under simultaneous mode switching and cyber attacks is a challenging open problem, since the asynchronous interplay among continuous dynamics, event-triggered impulses, and aperiodic ...
Ting Zhuang, Shuo Yin, Xiaoyu Zhang, Jilu Wang   +3 more
doaj   +1 more source

A Switching-Method for nonlinear systems

Journal of Computational and Applied Mathematics, 1996
The paper is intended to present an iterative method for the solution of nonlinear equations. This method consist in combining a direct search method and a damped approximate Newton method in order to avoid the computation of the Jacobian. The obtained hybrid method (called switching-method, due to the fact that at each iteration just one of the above ...
BELLAVIA, STEFANIA, GASPARO, MARIA GRAZIA, MACCONI, MARIA   +2 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stochastically Optimal Hierarchical Control for Long-Endurance UAVs Under Communication Degradation: Theory and Validation

Drones
This paper establishes a theoretical framework for treating communication quality as a navigable resource in long-endurance unmanned aerial vehicle (UAV) control under stochastic degradation.
Mosab Alrashed, Ali Fenjan, Humoud Aldaihani, Mohammad Alqattan   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Delay-Independent Stability of Switched Linear Systems with Unbounded Time-Varying Delays

Abstract and Applied Analysis, 2012
This paper is focused on delay-independent stability analysis for a class of switched linear systems with time-varying delays that can be unbounded. When the switched system is not necessarily positive, we first establish a delay-independent stability ...
Yuangong Sun
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Finite-time stabilization of switched linear systems and its application in terminal guidance

International Journal of Advanced Robotic Systems, 2016
This article presents finite-time stabilization methods of switched linear systems with disturbances. After extending finite-time stabilization and finite-time boundedness definitions to switched linear systems, sufficient conditions guaranteeing system ...
Yang Guo, Xiaoxiang Hu, Biao Deng, Shuai Zhang, Yu Jiang   +4 more
doaj   +1 more source