From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Radar High-Resolution Range Profile Target Recognition by the Dual Parallel Sequence Network Model
Using traditional neural network algorithms to adapt to high-resolution range profile (HRRP) target recognition is a complex problem in the current radar target recognition field. Under the premise of in-depth analysis of the long short-term memory (LSTM)
Jizhou Wu, Hongmin Zhang, Xuanhao Gao
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Aircraft Individual GRU Recognition Algorithm Based on Interpretable Track Features
Aiming at the technical bottlenecks existing in aircraft individual identification in battlefield situation awareness—including problems such as the prominent availability of single-dimensional data due to environmental constraints of multisource ...
Zekai Wu +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Direction-of-Arrival Estimation for Both Uncorrelated and Coherent Signals in Coprime Array
Direction-of-arrival (DOA) estimation in coprime array involves the problem that there is the coexistence of both uncorrelated signals and coherent signals in the multipath environment.
Haiyun Xu +4 more
doaj +1 more source
A Transceiver Design Based on an Autoencoder Network for Multi-Color VLC Systems
We propose a transceiver design method based on an autoencoder (AE) network for multi-color visible light communication (VLC) systems. Taking into account the chromaticity constraint described by MacAdam ellipses and the peak-value constraint of ...
Dong-Fang Zhang +3 more
doaj +1 more source
A new rasorber with a switchable transmission/reflection band between two wide absorption bands is proposed based on an ultrathin low‐profile frequency selective surface.
Min Tang +5 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source

