Results 51 to 60 of about 2,136,839 (361)

Intermittent metabolic switching, neuroplasticity and brain health

open access: yesNature Reviews Neuroscience, 2018
During evolution, individuals whose brains and bodies functioned well in a fasted state were successful in acquiring food, enabling their survival and reproduction.
M. Mattson   +4 more
semanticscholar   +1 more source

How to switch a master switch

open access: yeseLife, 2013
The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras.
Hein, Christopher   +2 more
openaire   +4 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effects of crosstalk in WDM optical label switching networks due to wavelength switching of a tunable laser [PDF]

open access: yes, 2006
rosstalk caused by switching events in fast tunable lasers in an optical label switching (OLS) system is investigated for the first time. A wavelength-division-multiplexed OLS system based on subcarrier multiplexed labels is presented which employs a 40 ...
Barry, Liam P.   +6 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Resistive switching in transition metal oxides

open access: yes, 2008
Rapid advances in information technology rely on high-speed and large-capacity nonvolatile memories. A number of alternatives to contemporary Flash memory have been extensively studied to obtain a more powerful and functional nonvolatile memory.
A. Sawa
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Novel Method for DOA and Time Delay Joint Estimation in Multipath OFDM Environment

open access: yesInternational Journal of Antennas and Propagation, 2020
Joint time delay and direction of arrival estimation based on uniform linear arrays in Orthogonal Frequency Division Multiplexing (OFDM) systems has to face the problems posed by coherent multipath environments and high computational complexity.
Xiangzhi Li   +4 more
doaj   +1 more source

Statins: to switch or not to switch? [PDF]

open access: yesPrescriber, 2008
Abstract Two doctors argue for and against the policy of switching patients from expensive branded statins to lower‐cost generic formulations in order to reduce NHS prescribing costs.
David Goldsmith, Martin Duerden
openaire   +1 more source

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