Results 71 to 80 of about 887,490 (255)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Indirect estimation of Markov switching models with endogenous switching [PDF]

Markov Switching models have been successfully applied to many economic problems. The most popular version of these models implies that the change in the state is driven by a Markov Chain and that the state is an exogenous discrete unobserved variable ...
Calzolari, Giorgio, Otranto, Edoardo, Di Iorio, Francesca   +2 more
core  

An algebraic method for moving source localization using TDOA, FDOA, and differential Doppler rate measurements with receiver location errors

EURASIP Journal on Advances in Signal Processing, 2019
To weaken the effect of receiver location error on localization accuracy and make the localization model closer to the practical scenario, this paper considers the receiver location errors, usually neglected in prior studies into the measurement model ...
Zhixin Liu, Dexiu Hu, Yongsheng Zhao, Yongjun Zhao   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Product innovation when consumers have switching costs [PDF]

Economists have long recognized that in free markets, incentives to innovate will be diluted unless some factors grant innovators with a temporary monopoly. Patenting is the most cited factor in the economic literature.
Salies, Evens
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Semantic IoT Service Communication—Impedance Matching Between Service Goal and Event Routing

International Journal of Distributed Sensor Networks
In IoT (Internet of Things) applications, there are many kinds of event flows. Without converging these flows based on their semantics, it is difficult to establish ultrascale-connected IoT service systems.
Yang Zhang, Bo Cheng, Junliang Chen
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Detecting Switching Strategies in Equity Hedge Funds [PDF]

Equity hedge funds are thought to effectively operate market timing by implementing switching strategies conditional on market circumstances. In this paper we use only the reported monthly returns on a set of funds to infer the type of switching ...
Carol Alexander, Anca Dimitriu
core  

Strategy-Based Gain Ratio Power Allocation in Non-Orthogonal Multiple Access for Indoor Visible Light Communication Networks

IEEE Access, 2019
Visible light communication (VLC) is an evolving green communication technology for indoor wireless communication networks. VLC utilizes light-emitting diodes (LEDs) for both illumination and communication.
Siyu Tao, Hongyi Yu, Qing Li, Yanqun Tang   +3 more
doaj   +1 more source