Results 101 to 110 of about 4,657,044 (399)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Beyond the Standard Model [PDF]

arXiv, 1995
A few topics beyond the standard model are reviewed.
arxiv  

Periodic fluctuations in correlation-based connectivity density time series: application to wind speed-monitoring network in Switzerland [PDF]

, 2017
In this paper, we study the periodic fluctuations of connectivity density time series of a wind speed-monitoring network in Switzerland. By using the correlogram-based robust periodogram annual periodic oscillations were found in the correlation-based network. The intensity of such annual periodic oscillations is larger for lower correlation thresholds
arxiv   +1 more source

Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland.

New England Journal of Medicine, 2004
BACKGROUND After the introduction of an inactivated intranasal influenza vaccine that was used only in Switzerland, 46 cases of Bell's palsy were reported. METHODS We conducted a matched case-control study and a case-series analysis.
Margot Mutsch, Weigong Zhou, P. Rhodes, M. Bopp, Robert T. Chen, T. Linder, C. Spyr, R. Steffen   +7 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Multipurpose use of hydropower reservoirs: Imaginaries of Swiss reservoirs in the context of climate change and dam relicensing

Water Alternatives, 2023
In the context of climate change, hydropower dams and reservoirs are being promoted as mitigation and adaptation tools. The reoperation of dam reservoirs is also being considered, particularly in countries where dams are currently undergoing ...
Silvia Flaminio, Emmanuel Reynard
doaj  

Madex Plus and Madex I12 overcome Virus Resistance of Codling Moth [PDF]

, 2008
Over the past three years, codling moth populations with resistance to the Mexican isolate of Cydia pomonella Granulovirus (CpGV) have been found in Germany, France, Italy, Switzerland and the Netherlands.
Zingg, D.
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Digital Rights to the City: Local Practices and Negotiations of Urban Space on Decidim

Urban Planning
The organization, management, and production of urban space through digital information and communication technologies have become a central means for governing urban life.
Aline Suter, Lars Kaiser, Martin Dušek, Florin Hasler, Simone Tappert   +4 more
doaj   +1 more source

Community detection analysis in wind speed-monitoring systems using mutual information-based complex network [PDF]

, 2018
A mutual information-based weighted network representation of a wide wind speed monitoring system in Switzerland was analysed in order to detect communities. Two communities have been revealed, corresponding to two clusters of sensors situated respectively on the Alps and on the Jura-Plateau that define the two major climatic zones of Switzerland.
arxiv   +1 more source