Results 81 to 90 of about 5,122,879 (337)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Quantifying food losses and the potential for reduction in Switzerland.
Waste Management, 2013 A key element in making our food systems more efficient is the reduction of food losses across the entire food value chain. Nevertheless, food losses are often neglected.
C. Beretta +3 more
semanticscholar +1 more source
Madex Plus and Madex I12 overcome Virus Resistance of Codling Moth [PDF]
, 2008 Over the past three years, codling moth populations with resistance to the Mexican isolate of Cydia pomonella Granulovirus (CpGV) have been found in Germany, France, Italy, Switzerland and the Netherlands.
Zingg, D.
core
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Studies in Communication Sciences, 2018 This article seeks to enrich the normative debate on the advantages and drawbacks of direct democracy through an empirical analysis of individual learning about the contents of ballot propositions during campaigns.
Laurent Bernhard
doaj +1 more source
Écrire au contact du français et du francoprovençal : la représentation de la diglossie dans quelques œuvres dialectales de France et de Suisse [PDF]
Revue Roumaine d’Etudes Francophones, 2019 In this paper, we study the presence of French/Franco Provencal (FP) diglossia in FP literature, whether original texts or translations. We discuss: 1) the presence of French passages in ‘classical’ FP literature in the western part of the FP region; 2 ...
Manuel MEUNE
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source