Results 61 to 70 of about 3,656,622 (302)

Unravelling the Entoloma politum complex

Plant and Fungal Systematics, 2023
Entoloma politum is a common lowland species in northern Europe. It has been described to have two close species with a more intense smell, E. nitriolens and E. pernitrosum . To clarify the taxonomy of these three species, the types of E. nitriolens
Katri Kokkonen
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evolution of a field: Swiss media and communication studies

Studies in Communication Sciences, 2019
In this paper, we present the evolution of Swiss Media and Communication Studies over the last decade by summarizing the main results from a project funded by the Swiss University Conference (2008–2017).
Carole Probst, Alexander Buhmann, Diana Ingenhoff, Benedetto Lepori   +3 more
doaj   +1 more source

The Image of a Tree in F.M. Dostoyevsky's Novel "The Idiot" [PDF]

Достоевский и мировая культура: Филологический журнал, 2018
The article is devoted to the analysis of the image of a tree in Dostoevsky’s novel “The Idiot”. The author reflects on the evolution of this image from an artistic detail in the description of the Pavlovsk Park to the philosophical symbol of the Golden ...
Olga N. Smyslova
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Global entrepreneurship monitor 2011 - Report on Switzerland.

, 2012
The following Global Entrepreneurship Monitor Report 2011 on Switzerland illustrates the differences in entrepreneurial attitudes, activity, and aspirations between economies, revealing the factors that determine the nature and level of national ...
Baldegger, Rico, Hacklin, Fredrik, Brülhart, Andreas, Alberton, Siegfried   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Structural and socio-cultural barriers to accessing mental healthcare among Syrian refugees and asylum seekers in Switzerland

European Journal of Psychotraumatology, 2020
Background: Due to their experiences of major stressful life events, including post-displacement stressors, refugees and asylum seekers are vulnerable to developing mental health problems.
Nikolai Kiselev, Monique Pfaltz, Florence Haas, Matthis Schick, Marie Kappen, Marit Sijbrandij, Anne M. De Graaff, Martha Bird, Pernille Hansen, Peter Ventevogel, Daniela C Fuhr, Ulrich Schnyder, Naser Morina   +12 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Household Role in Coping with Precarious Work. Evidence from Qualitative Research in Urban Romania and Switzerland

Social Change Review, 2016
This paper presents the results of a qualitative comparative study that looked at the meaning of ‘precarious work’ in households situated in the position of ‘precarious prosperity’ in Switzerland and Romania in 2013.
Preoteasa Ana Maria D., Sieber Rebekka, Budowski Monica, Suter Christian   +3 more
doaj   +1 more source