Results 41 to 50 of about 3,430,759 (315)
Meteorologische Zeitschrift, 1993 A detailed analysis of wind measurements from ground stations and upper air soundings leads to a description of the four-dimensional wind field during one day of the intensive observational phase of POLLUMET, July 5th, 1991.
Werner K. Graber, Werner Portmann
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Scandinavian Journal of Work, Environment & HealthOBJECTIVE: This study aimed to investigate the effect of a 12-week multi-component intervention on neck pain among Swiss office workers. METHODS: Between January 2020 and April 2021, we conducted a stepped-wedge cluster randomized controlled trial ...
Andrea Martina Aegerter +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Enforcing the rights of migrants with irregular status: City ID cards as a remedy?
Cognitio, 2021 Migrants who live in Switzerland without valid residence papers find themselves in a complex and contradictory legal position. Even though they are entitled to a great number of rights, they are rarely able to claim them in practice.
Irina Fehr
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2020 PEN 17 16 DIP, Regionalgericht Emmental-Oberaargau, Strafabteilung (Regional Court Emmental-Oberaargau, Criminal Division), 30 May 2018 Switzerland; criminal law; traffic violation; Autobahn; Tesla motor vehicle ‘Traffic-Aware Cruise Control’ and ...
Case translation, Switzerland:
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