Results 41 to 50 of about 3,189,034 (286)

Modeling wind fields over complex terrain by superposition of scale-related processes and its application to the Alpine air mass exchange

open access: yesMeteorologische Zeitschrift, 1993
A detailed analysis of wind measurements from ground stations and upper air soundings leads to a description of the four-dimensional wind field during one day of the intensive observational phase of POLLUMET, July 5th, 1991.
Werner K. Graber, Werner Portmann
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A multi-component intervention (NEXpro) reduces neck pain: a randomized controlled trial among Swiss office workers

open access: yesScandinavian Journal of Work, Environment & Health
OBJECTIVE: This study aimed to investigate the effect of a 12-week multi-component intervention on neck pain among Swiss office workers. METHODS: Between January 2020 and April 2021, we conducted a stepped-wedge cluster randomized controlled trial ...
Andrea Martina Aegerter   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Enforcing the rights of migrants with irregular status: City ID cards as a remedy?

open access: yesCognitio, 2021
Migrants who live in Switzerland without valid residence papers find themselves in a complex and contradictory legal position. Even though they are entitled to a great number of rights, they are rarely able to claim them in practice.
Irina Fehr
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Older Refugees: Strategies in Dealing With Denied Recognition

open access: yesSwiss Journal of Sociology, 2020
Until now the topic linking age and the moment of fleeing one’s country of origin have been of scientific interest only rarely. Older refugees have hardly attracted scientific attention.
Jurt Luzia, Sperisen Vera
doaj   +1 more source

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