Results 91 to 100 of about 305,225 (351)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The analysis of integration process of Ukraine into the European Union [PDF]
, 2019 Positive and negative consequences of the introduction of Ukraine into the European Union on economic, political, and social levels are analyzed in the article.
Karlyuk, S. V., Koschiyenko, M. V.
core
A Case Study Approach for Managing Risks & Challenges When Expanding to Emerging Markets [PDF]
, 2019 Globalization created new opportunities and many companies decide to expand to take advantage of these opportunities to improve their competitiveness.
Fragouli, Evangelia, Nikolaidou, Zoi
core +3 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The Application of Analyses in Industrial Commodity Trade in Croatia
Acta Economica et Turistica, 2021 After the corona virus pandemic is over, we can expect significant changes in management systems due to a further decrease in industrial commodity trade and, simultaneously, an increase in service trade, digital technology services in particular.
Zvonko Merkaš +2 more
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Strategic Planning of Medical Tourism with an Emphasis on Religious Tourism in Mashhad City
تحقيقات جغرافيايی, 2016 Medical tourism is a branch of health tourism that has grown considerably in many parts of the world now days. Mashhad city with regard to the Holy Shrine, More than 300 thousand foreign tourists per year, more than 31 public and private hospitals and ...
Ali Hajinejad +2 more
doaj
A Study on the Impact of ICT on Collaborative Learning Processes in Libyan Higher Education [PDF]
, 2015 This paper presents the conclusions of a study on the impact of ICT on collaborative learning processes in Libyan Higher Education (LHE). The quantitative analysis of the answers to a questionnaire (completed by Libyan full-time lecturers at the ...
Elzawi, Abdussalam +3 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source