Results 71 to 80 of about 146,307 (259)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Teknik Pemanfaatan Analisis Swot Tanpa skala Industri (A-swot-Tsi)

, 2003
Analisis SWOT telah lama dikenal dikalangan para ahli manajemen strategis yang banyak dimanfaatkan untuk menganalisis kondisi persaingan usaha. Sedemikian pentingnya hingga hampir tidak ada studi kelayakan usaha yang dapat diterima dengan baik sebelum ...
Putong, Iskandar
core  

Country Risk Assessment for Foreign Investments Using Neutrosophic PESTEL-SWOT [PDF]

Neutrosophic Sets and Systems
Purpose of the study: To measure country risks for foreign direct investments by assessing a neutrosophic PESTEL-SWOT. Design/methodology/approach: The PESTEL assessment includes political, economic, social, technological, environmental, and legal ...
Pablo San Andrés Reyes, Rafael Sorhegui-Ortega, Fidel Márquez-Sánchez, Andrés Renato Jácome Gagñay, Petr Sed'a   +4 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

European SWOT analysis on education for environmental citizenship

, 2019
A cidadania ambiental é crucial para o sucesso de qualquer política ambiental. O desenvolvimento sustentável, uma economia circular, uma economia de baixo carbono e uma bioeconomia exigem um envolvimento efetivo dos cidadãos.
Hadjichambis, Andreas Ch., Paraskeva-Hadjichambi, Demetra, Reis, Pedro   +2 more
core   +3 more sources

Analysis of waste handling strategies for riverbanks communities

JPPI (Jurnal Penelitian Pendidikan Indonesia)
Waste management is essential to protecting the environment and minimizing its negative impact on human health and the ecosystem. The low participation of riverbank residents in maintaining and creating a clean environment in the river and its ...
Muhammad Riduansyah Syafari, M. Nur Iman Ridwan, Sugiannor Sugiannor, Syahrial Shaddiq   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Wae Bobok Tourism Potential: Mapping a Destination in West Manggarai, East Nusa Tenggara

Soshum: Jurnal Sosial dan Humaniora
West Manggarai is one of the districts in East Nusa Tenggara that has been visited by tourists, unfortunately, the purpose of the visit is dominant to the city of Labuan Bajo. Many tourism potentials in West Manggarai have been known, widely praised, and
L. K. Herindiyah Kartika Yuni, I Wayan Kartimin   +1 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Trends and policy issues for the e-learning implementation in Libyan universities [PDF]

, 2014
This paper provides an overview the current trends and the policy issues for e-learning implementation in Libyan universities LUs.; where is present a sample model to comparative between two questionnaires in 2009& 2013; as a technique to evolution the e-
Pislaru, Crinela, Elzawi, A., Kenan, Thuraya   +2 more
core   +1 more source