Results 101 to 110 of about 25,985,256 (227)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

Teknik Pemanfaatan Analisis Swot Tanpa skala Industri (A-swot-Tsi)

open access: yes, 2003
Analisis SWOT telah lama dikenal dikalangan para ahli manajemen strategis yang banyak dimanfaatkan untuk menganalisis kondisi persaingan usaha. Sedemikian pentingnya hingga hampir tidak ada studi kelayakan usaha yang dapat diterima dengan baik sebelum ...
Putong, Iskandar
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Energy Efficiency Strategically Planning: SWOT Analysis

open access: yes
Aim of this article is to research of problems and directions of resolving one’s what appears with new challenges what was set up during independence years when Latvia’ s economy depend on imported energy sources. Other direction is to set up the list of
Geipele, Ineta   +3 more
core  

SWOT Analysis in Enhancing School Competitiveness in the Era of Globalization: A Strategic Approach Based on Educational Management

open access: yesUrwatul Wutsqo
This study aims to analyze the utilization of SWOT analysis in enhancing school competitiveness in the era of globalization. The research employs a qualitative descriptive approach with a library research design by systematically reviewing relevant ...
Chelsi Hestivik   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

The Peculiarities of Application of SWOT Analysis in Crisis Management

open access: yes
The aim of the work is to give characteristics of the SWOT-analysis, to decode its components using schematic display of the process of occurrence of a crisis situation, in which the influence of factors of the external and internal environment of the ...
Kolomeičuka, Irina   +1 more
core  

Strategy evaluation of industrial enterprises in business process reengineering in manufacturing [PDF]

open access: yesMarketing i Menedžment Innovacij, 2014
The aim of the article. The article discusses the issues of strategic evaluation of the industrial enterprises in reengineering business processes in production at the project level. The aim of the article is to improve methods of strategic assessment of
L.M. Taraniuk
doaj  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

SWOT ANALYSIS OF UNDERGRADUATE AND POSTGRADUATE MEDICAL TRAINING PROGRAMS IN OCCUPATIONAL HEALTH

open access: yes
Objectives. Carrying out SWOT analysis of undergraduate and postgraduate training programs to identify factors that may affect the quality, sustainability, and relevance of the program, with the aim of contributing to the training of occupational health ...
Serghei CEBANU   +4 more
core   +1 more source

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