Results 51 to 60 of about 1,987,653 (293)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Indoor localization algorithm based on artificial neural network and radio-frequency identification reference tags

Advances in Mechanical Engineering, 2018
With the development of Internet of Things technology, radio-frequency identification localization methods have been widely applied due to their low cost and ease of deployment.
Quangang Wen, Yanchun Liang, Chunguo Wu, Adriano Tavares, Xiaosong Han   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An Image Histogram Equalization Acceleration Method for Field-Programmable Gate Arrays Based on a Two-Dimensional Configurable Pipeline

Sensors
New artificial intelligence scenarios, such as high-precision online industrial detection, unmanned driving, etc., are constantly emerging and have resulted in an increasing demand for real-time image processing with high frame rates and low power ...
Yan Wang, Peirui Liu, Dalin Li, Kangping Wang, Rui Zhang   +4 more
doaj   +1 more source

Lncident: A Tool for Rapid Identification of Long Noncoding RNAs Utilizing Sequence Intrinsic Composition and Open Reading Frame Information

International Journal of Genomics, 2016
More and more studies have demonstrated that long noncoding RNAs (lncRNAs) play critical roles in diversity of biological process and are also associated with various types of disease.
Siyu Han, Yanchun Liang, Ying Li, Wei Du
doaj   +1 more source

Relating brain structure images to personality characteristics using 3D convolution neural network

CAAI Transactions on Intelligence Technology, 2021
The Keras deep learning framework is employed to study MRI brain data in a preliminary analysis of brain structure using a convolutional neural network. The results obtained are matched with the content of personality questionnaires.
Lixian Cao, Yanchun Liang, Wei Lv, Kaechang Park, Yasuhiro Miura, Yuki Shinomiya, Shinichi Yoshida   +6 more
doaj   +1 more source

De novo Prediction of Moonlighting Proteins Using Multimodal Deep Ensemble Learning

Frontiers in Genetics, 2021
Moonlighting proteins (MPs) are a special type of protein with multiple independent functions. MPs play vital roles in cellular regulation, diseases, and biological pathways. At present, very few MPs have been discovered by biological experiments. Due to
Ying Li, Jianing Zhao, Zhaoqian Liu, Cankun Wang, Lizheng Wei, Siyu Han, Wei Du   +6 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

MMGAT: a graph attention network framework for ATAC-seq motifs finding

BMC Bioinformatics
Background Motif finding in Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) data is essential to reveal the intricacies of transcription factor binding sites (TFBSs) and their pivotal roles in gene regulation.
Xiaotian Wu, Wenju Hou, Ziqi Zhao, Lan Huang, Nan Sheng, Qixing Yang, Shuangquan Zhang, Yan Wang   +7 more
doaj   +1 more source

Multilayer Perceptron Network Optimization for Chaotic Time Series Modeling

Entropy, 2023
Chaotic time series are widely present in practice, but due to their characteristics—such as internal randomness, nonlinearity, and long-term unpredictability—it is difficult to achieve high-precision intermediate or long-term predictions.
Mu Qiao, Yanchun Liang, Adriano Tavares, Xiaohu Shi   +3 more
doaj   +1 more source