Results 61 to 70 of about 1,385,865 (356)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Bootstrap Dynamical Symmetry Breaking

open access: yesAdvances in High Energy Physics, 2013
Despite the emergence of a 125 GeV Higgs-like particle at the LHC, we explore the possibility of dynamical electroweak symmetry breaking by strong Yukawa coupling of very heavy new chiral quarks
Wei-Shu Hou
doaj   +1 more source

Nematicity with a twist: Rotational symmetry breaking in a moiré superlattice [PDF]

open access: yesScience Advances, 2019
Twisted 2D materials realize a unique electronic nematic state, quite different from its counterpart in bulk quantum materials. Motivated by recent reports of nematic order in twisted bilayer graphene (TBG), we investigate the impact of the triangular ...
R. Fernandes, J. Venderbos
semanticscholar   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

open access: yesFEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel   +3 more
wiley   +1 more source

Spontaneous symmetry breaking of coupled Fabry–Pérot nanocavities

open access: yesCommunications Physics
Ring cavities are quickly emerging as preferential platforms to investigate spontaneous symmetry breaking. However, research on handedness polarisation splitting within Kerr-coupled cavities is yet at a preliminary stage.
Jianming Mai   +4 more
doaj   +1 more source

Time-reversal symmetry breaking type-II Weyl state in YbMnBi2

open access: yesNature Communications, 2019
Spectroscopic detection of Dirac and Weyl fermions in real materials is vital for both, promising applications and fundamental bridge between high-energy and condensed-matter physics.
S. Borisenko   +14 more
semanticscholar   +1 more source

Breaking Anti-PT Symmetry by Spinning a Resonator.

open access: yesNano letters (Print), 2020
Non-Hermitian systems, with symmetric or antisymmetric Hamiltonians under the parity-time (PT) operations, can have entirely real or imaginary eigenvalues.
Huilai Zhang   +6 more
semanticscholar   +1 more source

Nature of Symmetry Breaking at the Excitonic Insulator Transition: Ta_{2}NiSe_{5}. [PDF]

open access: yesPhysical Review Letters, 2019
Ta_{2}NiSe_{5} is one of the most promising materials for hosting an excitonic insulator ground state. While a number of experimental observations have been interpreted in this way, the precise nature of the symmetry breaking occurring in Ta_{2}NiSe_{5},
G. Mazza   +7 more
semanticscholar   +1 more source

Breaking Value Symmetry [PDF]

open access: yes, 2007
Symmetry is an important factor in solving many constraint satisfaction problems. One common type of symmetry is when we have symmetric values. In a recent series of papers, we have studied methods to break value symmetries. Our results identify computational limits on eliminating value symmetry. For instance, we prove that pruning all symmetric values
openaire   +4 more sources

Analysis of Temperature and Stress Distribution on the Bond Properties of Hybrid Tailored Formed Components

open access: yesAdvanced Engineering Materials, EarlyView.
Hybrid materials enable high‐performance components but are challenging to process. This study explores an inductive heating concept with spray cooling for steel–aluminum specimens in a two‐step process including friction welding and cup backward extrusion.
Armin Piwek   +7 more
wiley   +1 more source

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