Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns : impact of design optimisation [PDF]
, 2019 Purpose: There is a need for alternative analgosedatives such as dexmedetomidine in neonates. Given the ethical and practical difficulties, protocol design for clinical trials in neonates should be carefully considered before implementation.
Allegaert, Karel +8 more
core +5 more sources
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.ABSTRACT Renal denervation (RDN) is an adjunct therapy for resistant hypertension, reducing blood pressure (BP) by inhibiting both afferent sensory and efferent sympathetic renal nerve activity. The resulting reduction in central sympathetic outflow including that directed toward the heart may beneficially impact cardiac remodeling, left ventricular ...
Gianni Sesa‐Ashton +12 more
wiley +1 more source
Sympathetic Nervous System Activation and Its Modulation: Role in Atrial Fibrillation
Frontiers in Neuroscience, 2019 The autonomic nervous system (ANS) has a significant influence on the structural integrity and electrical conductivity of the atria. Aberrant activation of the sympathetic nervous system can induce heterogeneous changes with arrhythmogenic potential ...
Revathy Carnagarin +6 more
doaj +1 more source
Physiological Effect of Ghrelin on Body Systems
International Journal of Endocrinology, 2020 Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of physiological effects. In this review, we found/confirmed that ghrelin has effect on all body systems. It induces appetite; promotes the use of carbohydrates as
Yonas Akalu +3 more
doaj +1 more source
Evaluation of sixteen antimotion sickness drugs under controlled laboratory conditions [PDF]
Evaluation of antimotion sickness drugs under controlled laboratory ...
Graybiel, A., Wood, C. D.
core +1 more source
A loading dose of 1 μg/kg and maintenance dose of 0.5 μg/kg/h of dexmedetomidine for sedation under spinal anesthesia may induce excessive sedation and airway obstruction [PDF]
, 2016 Background: For many drugs, dosing scalars such as ideal body weight (IBW) and lean body mass are recommended over the use of total body weight (TBW) during weight-based dose calculations. Doses based on TBW are frequently used, and this may cause under-
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Characteristics, Management, and Outcomes of Hospitalized Patients with Orthostatic Hypotension
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.ABSTRACT Orthostatic hypotension (OH) is a common inpatient condition associated with falls, syncope, and mortality. However, standardized approaches for inpatient management of OH are lacking and may vary across clinical specialties. In this retrospective observational cohort study, we reviewed the electronic medical records of patients admitted to ...
Benjamin A. Wagner +5 more
wiley +1 more source
Resistant and refractory hypertension: two sides of the same disease?
Brazilian Journal of Nephrology, 2018 Refractory hypertension (RfH) is an extreme phenotype of resistant hypertension (RH), being considered an uncontrolled blood pressure besides the use of 5 or more antihypertensive medications, including a long-acting thiazide diuretic and a ...
Elizabeth Silaid Muxfeldt +2 more
doaj +1 more source
Blood pressure changes after renal denervation at 10 European expert centers [PDF]
, 2013 We did a subject-level meta-analysis of the changes (Δ) in blood pressure (BP) observed 3 and 6 months after renal denervation (RDN) at 10 European centers. Recruited patients (n=109; 46.8% women; mean age 58.2 years) had essential hypertension confirmed
Adiyaman, A +26 more
core +3 more sources
Spontaneous and pharmacologically induced hypothermia protect mice against endotoxic shock
British Journal of Pharmacology, Volume 182, Issue 12, Page 2621-2641, June 2025.Background and Purpose Despite the well‐known occurrence of hypothermia during sepsis, its underlying biological nature and adaptive value remain debated. Experimental Approach Using indirect calorimetry, telemetry, thermal gradient studies and pharmacological studies, we examined the thermal and metabolic responses of mice treated with a shock ...
Arely Tinajero +7 more
wiley +1 more source