Results 51 to 60 of about 1,200 (185)

Impact of early dexmedetomidine administration on short‐ and long‐term outcomes in critically traumatic brain injury patients: A retrospective study using the MIMIC‐IV database

Ibrain, Volume 12, Issue 1, Page 137-150, Spring 2026.
Our retrospective analysis of the Medical Information Mart for Intensive Care‐IV (MIMIC‐IV) database suggests that early use of dexmedetomidine is associated with lower short‐term (28‐day and in‐hospital) and long‐term (1‐year) mortality in patients with traumatic brain injury.
Yang Long, Long‐Zhen Liu, Xiao‐Xue Tan, Yong‐Hu Zhang, Cheng‐Xi Liu, Shan Liu, Wen‐Jie Liu   +6 more
wiley   +1 more source

The effect of sex on the isolated and combined α‐ and β‐adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study

Physiological Reports, Volume 14, Issue 3, February 2026.
Abstract This study examined how sex influences blood flow during exercise at altitude and relative contributions of adrenergic mechanisms. Thirteen participants (8 M/5F) were tested at low and high altitude (days 3–11). Participants performed rhythmic handgrip for 3 min at 25% maximal voluntary contraction during local infusions of saline, propranolol
Lauren E. Maier, Emily R. Vanden Berg, Lydia Simpson, Michiel Ewalts, Katharine Foster, Jared Baylis, Christopher Gasho, David Macleod, Sean van Diepen, James Anholm, Justin Lawley, Philip N. Ainslie, Travis D. Gibbons, Michael Stembridge, Jonathan Moore, Craig D. Steinback   +15 more
wiley   +1 more source

Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension

, 2010
The pathogenesis of hypertension and its mode of progression are complex, multifactoral and incompletely understood. However, there is accumulating evidence from humans and animal models of hypertension indicating that excessive central sympathetic nerve
Fadel, PJ, Fisher, James
core   +1 more source

Effects of Dexmedetomidine on the Behavioral Outcomes in Streptozotocin‐Induced Alzheimer's Disease Rats

Brain and Behavior, Volume 16, Issue 1, January 2026.
Dexmedetomidine at 25 µg/kg effectively reverses working and spatial memory deficits in a streptozotocin (STZ)‐induced rat model of Alzheimer's disease, restoring Y‐maze alternation and Morris Water Maze performance. Higher doses show no clear benefit, highlighting Dex‐25 as a promising neuroprotective candidate.
Mina Mohasel‐Roodi, Masoumeh Nozari, Ali Shamsara, Mohsen Basiri, Vida Mirzaie, Masoumeh Baghalishahi   +5 more
wiley   +1 more source

Single‐Shot Intrathecal Bupivacaine With Fentanyl vs. Dexmedetomidine for Labor Analgesia: A Randomized Controlled Trial

Anesthesiology Research and Practice, Volume 2026, Issue 1, 2026.
Background Labor pain is one of the most intense physiological pains experienced by women. Single‐shot spinal analgesia (SSSA) offers rapid and reliable labor pain relief. Combining bupivacaine with adjuvants like fentanyl or dexmedetomidine has been proposed to enhance analgesic efficacy and maternal comfort.
Ayman Mohamady Eldemrdash, Taha Tairy Dardeer Elsawy, Zaher Zaki Zaher, Jehan Sadek Younan, Ahmed Mohammed Reda Ragheb, Srijoni Sengupta   +5 more
wiley   +1 more source

Hemodynamic Effects of Opioid‐Free Anesthesia Versus Opioid Anesthesia in Supratentorial Tumor Excision: A Randomized Controlled Trial

Anesthesiology Research and Practice, Volume 2026, Issue 1, 2026.
Background In view of analgesia and hemodynamic control in cranial surgeries, opioids have been used for decades. However, the use of opioids is not devoid of side effects. The current study was designed to evaluate opioid‐free anesthesia (OFA) as an alternative to opioid anesthesia (OA) in cranial surgeries for supratentorial tumors.
Rania Samir Fahmy, Haitham Mohamed Hassan Kassem, Omar Wagih Abbas, Hesham Abdelwahab Abu el Dahab, Mohamed Mahmoud Mohamed, Dalia Saad Abd El Kader, Safinaz Hassan Osman, Srijoni Sengupta   +7 more
wiley   +1 more source

The Sympathetic Nervous System in Heart Failure Physiology, Pathophysiology, and Clinical Implications

, 2009
Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers countermeasures aimed to restore cardiac output. These responses are compensatory at first but eventually become part of the disease process itself leading ...
Skoularigis, John, Louridas, George, Karayannis, George, Triposkiadis, Filippos, Butler, Javed, Giamouzis, Grigorios   +5 more
core   +1 more source

Testing of Chromatographic Qualities of Alternative Stationary Phases [PDF]

, 2011
1 Abstract Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Michaela Havlátová Consultant: Doc. RNDr. Dalibor Šatínský, PhD.
Havlátová, Michaela
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Chronically elevated sympathetic nervous system tone: A significant, common, and poorly realised contributor to cardiometabolic disease in type 2 diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1595-1598, March 2026.
Ralph A. DeFronzo
wiley   +1 more source

Uzun süreli antihipertansif ilaç kullanımının kemik yoğunluğuna etkisinin dental volumetrik tomografi ile değerlendirilmesi [PDF]

, 2021
Hipertansiyon (HT) ya da yüksek kan basıncı ortalama arter kan basıncının normal olarak belirlenmiş değerlerin üzerinde olmasıdır. HT, sürekli kan basıncı yüksekliği ile kendini gösteren, sistemik bir hastalık olup, ciddi komplikasyonlara neden olması ve
Güler, Rıdvan
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