Results 31 to 40 of about 1,242 (177)

Pharmacologic pitfalls in heart failure: a guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document

Heart failure (HF) exerts a global health burden, often complicated by polypharmacy due to the frequent coexistence of cardiovascular and non-cardiovascular comorbidities.
Hadi Skouri (5314571), Muthiah Vaduganathan (6645596), Michael Böhm (65063), Marco Metra (300433), Suleman Aktaa (21386291), Amr Abdin (16940782), Seif Yahia Salah Elhadidi (20458448), Antonio Bayes-Genis (23481111), Wilfried Mullens (3422597), Hussam Al Ghorani (23481110), Jan Biegus (23481112), Gianluigi Savarese (291020), Nicolas Girerd (585508), Magdy Abdelhamid (11162607), Johann Bauersachs (141016), Giuseppe M C Rosano (23481120), Javed Butler (174923)   +16 more
core   +3 more sources

Dexmedetomidine in cardiac surgery: Emphasis on interleukin-18 signaling pathway [PDF]

Journal of Clinical and Basic Research
Background: Dexmedetomidine (Dex), a non-opioid anesthetic and highly selective alpha2 (α2) adrenergic receptor agonist, exerts beneficial effects by mitigating inflammation and myocardial injury during cardiac surgery.
Bassim Mohammed Jabbar Hatemi, Ayesheh Enayati, Ali Movafegh, Ali Jabbari   +3 more
doaj  

Prophylactic Dexmedetomidine Reduces Junctional Ectopic Tachycardia and Facilitates Postoperative Recovery in Pediatric Cardiac Surgery: A Systematic Review and Meta‐Analysis of Prospective Trials

Pediatric Anesthesia, Volume 36, Issue 7, Page 767-777, July 2026.
ABSTRACT Objective To evaluate the efficacy and safety of prophylactic dexmedetomidine in preventing Junctional Ectopic Tachycardia (JET) and its impact on postoperative recovery in pediatric congenital heart surgery, restricting analysis to prospective trials. Methods We systematically searched PubMed, Scopus, and CENTRAL through October 16, 2025, for
Michelle Singh, Arjun Anilkumar, Rohit Vondivillu Srinivasan, Jasim Abdul Jabbar, Naghul Malaichamy, Rethin Jayaraman   +5 more
wiley   +1 more source

Combination pharmacotherapy for psychiatric disorders in children and adolescents: prevalence, efficacy, risks and research needs

, 2013
Polypharmacy, defined as the concomitant use of two or more psychotropic drugs, has become increasingly common in the paediatric and adolescent population over the past two decades.
Jureidini, E., Jureidini, J., Tonkin, A.
core   +1 more source

Oxidative stress and impaired cardiovagal baroreflex sensitivity in young adults with post‐traumatic stress disorder

Experimental Physiology, Volume 111, Issue 7, Page 3216-3227, 1 July 2026.
Abstract Post‐traumatic stress disorder (PTSD) is associated with elevated cardiovascular disease (CVD) risk, yet the underlying physiological characterization in young adults remain unclear. This study examines whether autonomic and/or vascular dysfunction predominates as an early precursor to CVD development in young adults with PTSD and explores the
Jennifer B. Weggen, Jacob W. Richardson, Emily A. Buck, Brad T. Bakken, Brandon J. Fitzpatrick, Raven G. Campbell, Ryan S. Garten   +6 more
wiley   +1 more source

RETROSPECTIVE STUDY OF THE EFFICACY OF LONG-TERM TREATMENT OF FELINE IDIOPATHIC CYSTITIS

Agricultura
The aim of our research was to determine the efficacy of long-term treatment of feline idiopathic cystitis. For this purpose, a population of 42 cats suffering from feline idiopathic cystitis was selected and divided into two groups.
Anca Bărbos, Vlad Luca, Alexandra Biriș, Radu Lăcătuș   +3 more
doaj   +1 more source

From Molecules to Machines: An Integrative Framework Linking Molecular Pathogenesis, Multi‐Factorial Risk, Risk Stratification, Clinical Management, and Artificial Intelligence in QT Prolongation and Sudden Cardiac Death

Clinical Cardiology, Volume 49, Issue 6, June 2026.
An integrative conceptual framework linking the five principal domains addressed in this review. Beginning at the molecular level, loss‐of‐function mutations in KCNQ1 and KCNH2 reduce outward repolarizing currents (IKs and IKr), while gain‐of‐function SCN5A mutations augment late inward sodium current (INa), establishing the genetic substrate for ...
Mojtaba Farjam, Mohammad Hosein Yazdanpanah, Narges Fereydouni   +2 more
wiley   +1 more source

USE OF CENTRALLY ACTING SYMPATHOLYTIC AGENTS IN THE MANAGEMENT OF HYPERTENSION

, 1991
Considerable evidence suggests that hyperactivity of the sympathetic nervous system is implicated not only in the pathogenesis of essential hypertension but also in several blood pressure-independent complications of essential hypertension. Even with the
Epstein, M, Oster, OSTER
core   +1 more source

The Sympathetic Nervous System in Heart Failure Physiology, Pathophysiology, and Clinical Implications [PDF]

, 2009
Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers countermeasures aimed to restore cardiac output. These responses are compensatory at first but eventually become part of the disease process itself leading ...
Skoularigis, John, Louridas, George, Karayannis, George, Triposkiadis, Filippos, Butler, Javed, Giamouzis, Grigorios   +5 more
core   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, Volume 3, Issue 2, Page 237-251, June 2026.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source