Results 31 to 40 of about 1,200 (185)

Next Step in Chronic Kidney Disease Therapy

, 2016
Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers are the basis of renoprotection therapy in chronic kidney disease. Parallel to decrease of glomerular filtration rate, there is an increase in the activity of the sympathetic nervous ...
D.D. Ivanov
core   +1 more source

Sex‐related differences in the peripheral vascular response to hypoxia: Implications in health and relevance for obstructive sleep apnoea

Experimental Physiology, EarlyView.
Abstract The incidence and presentation of obstructive sleep apnoea, as well as hypertension and cardiovascular disease, have been reported to differ by sex. It is thus reasonable to propose mechanisms contributing to subsequent pathology differ by sex. This concept is supported from a pre‐pathological perspective, as sex differences have been observed
Dain W. Jacob, Sara E. Mascone, Natasha G. Boyes, Anna M. Gonsalves, Jacqueline K. Limberg   +4 more
wiley   +1 more source

Pharmacological Treatment of Posttraumatic Stress Disorder

, 2015
Although psychotherapy is considered first-line treatment for posttraumatic stress disorder (PTSD), advances have been made in pharmacological treatment. Based on controlled clinical trials, antidepressants remain the first-line pharmacological treatment.
Emily Chapman, Julia A. Golier, Andreas C. Michaelides, Maya Genovesi, Rachel Yehuda   +4 more
core   +1 more source

Oxidative stress and impaired cardiovagal baroreflex sensitivity in young adults with post‐traumatic stress disorder

Experimental Physiology, EarlyView.
Abstract Post‐traumatic stress disorder (PTSD) is associated with elevated cardiovascular disease (CVD) risk, yet the underlying physiological characterization in young adults remain unclear. This study examines whether autonomic and/or vascular dysfunction predominates as an early precursor to CVD development in young adults with PTSD and explores the
Jennifer B. Weggen, Jacob W. Richardson, Emily A. Buck, Brad T. Bakken, Brandon J. Fitzpatrick, Raven G. Campbell, Ryan S. Garten   +6 more
wiley   +1 more source

Nasal airflow in health and disease

, 2000
This review examines our present understanding of the physiology, pathophysiology and pharmacology of nasal airflow. The main aim of the review is to discuss the basic scientific and clinical knowledge that is essential for a proper understanding of the ...
Eccles, Ronald
core   +1 more source

Dexmedetomidine in cardiac surgery: Emphasis on interleukin-18 signaling pathway [PDF]

Journal of Clinical and Basic Research
Background: Dexmedetomidine (Dex), a non-opioid anesthetic and highly selective alpha2 (α2) adrenergic receptor agonist, exerts beneficial effects by mitigating inflammation and myocardial injury during cardiac surgery.
Bassim Mohammed Jabbar Hatemi, Ayesheh Enayati, Ali Movafegh, Ali Jabbari   +3 more
doaj  

Optimized SPE‐HPLC‐FLD Method for the Simultaneous Determination of Olaparib, Propranolol, and Furosemide in Human Urine

Biomedical Chromatography, Volume 40, Issue 8, August 2026.
ABSTRACT Olaparib belongs to the PARP inhibitors and is widely used as an anticancer drug. Due to frequent side effects, it is usually co‐administered with an antihypertensive, such as propranolol and/or an antidiuretic, such as furosemide. In this study, a highly sensitive HPLC‐FLD method was developed for the simultaneous determination of the three ...
Georgios Kamaris, Antonia Kalagia, Catherine K. Markopoulou   +2 more
wiley   +1 more source

Prophylactic Dexmedetomidine Reduces Junctional Ectopic Tachycardia and Facilitates Postoperative Recovery in Pediatric Cardiac Surgery: A Systematic Review and Meta‐Analysis of Prospective Trials

Pediatric Anesthesia, Volume 36, Issue 7, Page 767-777, July 2026.
ABSTRACT Objective To evaluate the efficacy and safety of prophylactic dexmedetomidine in preventing Junctional Ectopic Tachycardia (JET) and its impact on postoperative recovery in pediatric congenital heart surgery, restricting analysis to prospective trials. Methods We systematically searched PubMed, Scopus, and CENTRAL through October 16, 2025, for
Michelle Singh, Arjun Anilkumar, Rohit Vondivillu Srinivasan, Jasim Abdul Jabbar, Naghul Malaichamy, Rethin Jayaraman   +5 more
wiley   +1 more source

From Molecules to Machines: An Integrative Framework Linking Molecular Pathogenesis, Multi‐Factorial Risk, Risk Stratification, Clinical Management, and Artificial Intelligence in QT Prolongation and Sudden Cardiac Death

Clinical Cardiology, Volume 49, Issue 6, June 2026.
An integrative conceptual framework linking the five principal domains addressed in this review. Beginning at the molecular level, loss‐of‐function mutations in KCNQ1 and KCNH2 reduce outward repolarizing currents (IKs and IKr), while gain‐of‐function SCN5A mutations augment late inward sodium current (INa), establishing the genetic substrate for ...
Mojtaba Farjam, Mohammad Hosein Yazdanpanah, Narges Fereydouni   +2 more
wiley   +1 more source

Combination pharmacotherapy for psychiatric disorders in children and adolescents: prevalence, efficacy, risks and research needs

, 2013
Polypharmacy, defined as the concomitant use of two or more psychotropic drugs, has become increasingly common in the paediatric and adolescent population over the past two decades.
Jureidini, E., Jureidini, J., Tonkin, A.
core   +1 more source