Results 101 to 110 of about 3,862 (291)

Feed‐Forward Deep Neural Networks Predict Substrate‐Specific Effects of Transporter Variants to Explain Drug Response Variability

open access: yesClinical and Translational Science
Genetic variants in drug transporter genes shape the interindividual variability in drug response. However, their functional interpretation has remained limited due to the substrate dependence of variant effects.
Yoomi Park   +4 more
doaj   +1 more source

Ergogenic and Sympathomimetic Effects of Yohimbine: A Review

open access: yesNeurology International
The purpose of this review is to compile and discuss available evidence in humans on the efficacy of YHM supplementation on performance in different exercise modalities.
Sophia L. Porrill   +2 more
doaj   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher   +12 more
wiley   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad   +9 more
wiley   +1 more source

Localizing value of cutaneous ictal phenomena: A systematic review

open access: yesEpileptic Disorders, EarlyView.
Abstract Objective Clinical observation of autonomic signs during seizures can aid in localizing the epileptogenic zone (EZ). We performed a systematic review and meta‐analysis to evaluate the localizing value of ictal cutaneous phenomena—piloerection, sweating, pallor, and flushing—in focal epilepsy and their relevance to presurgical evaluation ...
R. Rocamora   +7 more
wiley   +1 more source

Elucidating the outpatient burden of lower respiratory tract infections due to RSV and other viruses in children under 2 years of age: Clinical presentation, medical treatment, and family impact (Germany, 11/2022-10/2024)

open access: yesInternational Journal of Infectious Diseases
Objectives: Worldwide, data on the burden of pediatric, outpatient-treated lower respiratory tract infections (LRTI) are limited. We investigated their viral etiology, clinical characteristics and family impact in Würzburg/Germany. Methods: Children aged
Katharina J. Hecker   +26 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

open access: yesEpilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Mecanismos de cardiotoxicidad: antineoplásicos, anti-inflamatorios no esteroideos, antipsicóticos, cocaetileno y simpaticomiméticos Mechanisms of cardiotoxicity: antineoplastics, nonsteroidal anti-inflammatory drugs, antipsychotics, cocaethylene and sympathomimetics

open access: yesRevista Colombiana de Cardiología, 2011
La interacción constante del organismo humano con diferentes sustancias, que incluso en muchas ocasiones se consideran inofensivas, tiene un alto impacto sobre todos los sistemas, siendo el cardiovascular uno de los más afectados.
Lukas Salazar   +2 more
doaj  

Ensuring optimal metabolism during coronary artery bypass grafting with cardiopulmonary bypass

open access: yesPatologìâ
Aim: to reduce perioperative complications in cardiac surgeries with cardiopulmonary bypass (CPB) by developing a comprehensive, personalized approach to ensure optimal tissue metabolism. Materials and methods.
V. I. Cherniy, L. O. Sobanska
doaj   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska   +4 more
wiley   +1 more source

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