Results 101 to 110 of about 4,147 (297)

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Feed‐Forward Deep Neural Networks Predict Substrate‐Specific Effects of Transporter Variants to Explain Drug Response Variability

Clinical and Translational Science
Genetic variants in drug transporter genes shape the interindividual variability in drug response. However, their functional interpretation has remained limited due to the substrate dependence of variant effects.
Yoomi Park, Yitian Zhou, Ming Xiao, Anne T. Nies, Volker M. Lauschke   +4 more
doaj   +1 more source

Drug Interactions with Guanethidine

, 1971
In view of the fact that many hypertensive patients on guanethidine receive a number of different drugs, it is essential to determine whether there is any drug interaction.
Ober, Karl Friedrich
core  

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Ergogenic and Sympathomimetic Effects of Yohimbine: A Review

Neurology International
The purpose of this review is to compile and discuss available evidence in humans on the efficacy of YHM supplementation on performance in different exercise modalities.
Sophia L. Porrill, Rebecca R. Rogers, Christopher G. Ballmann   +2 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Elucidating the outpatient burden of lower respiratory tract infections due to RSV and other viruses in children under 2 years of age: Clinical presentation, medical treatment, and family impact (Germany, 11/2022-10/2024)

International Journal of Infectious Diseases
Objectives: Worldwide, data on the burden of pediatric, outpatient-treated lower respiratory tract infections (LRTI) are limited. We investigated their viral etiology, clinical characteristics and family impact in Würzburg/Germany. Methods: Children aged
Katharina J. Hecker, Hanna Bethe, Géraldine Engels, Kerstin Knies, Christine Krempl, Benedikt Weissbrich, Johannes Liese, Andrea Streng, Wolfgang Brosi, Elke Brosi, Simon Berzel, Kathrin Heinke, Henrike Zillhardt, Gabriele Lieb, Uwe Sack, Silvia Glotzbach-Sack, Margarethe Kozuschek, Johannes Hausmann, Anna Weber, Stephan Jarosch, Manuel Langer, Annette Hein, Martin Herbst, Heike Backmann, Anna-Teresa Schneiderbanger, Roland Metzner, Christa Kitz   +26 more
doaj   +1 more source

Dietary Artificial Sweeteners: From Chemical Transformation in Food to Gut Microbial Processing

ChemFoodChem, EarlyView.
This review article unites classical and recent findings on the stability of artificial sweeteners in food. The focus is on ten sweeteners approved in the European Union: their chemical stability during processing and storage, individual degradation products, and their interactions with the intestinal microbiota.
Jürgen Lassak, Michael Hellwig
wiley   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Pharmacological aspects of β [beta]-adrenoceptor stimulants

, 1976
Deposited with permission of the author. © 1976 Dr. Errol MaltaSummary: Structure-activity relationships of non-catecholamine sympathomimetics have been studied in isolated tissue preparations from the guinea-pig and in anaesthetized cats.
Malta, Errol
core   +1 more source