Results 91 to 100 of about 3,868 (289)

Feed‐Forward Deep Neural Networks Predict Substrate‐Specific Effects of Transporter Variants to Explain Drug Response Variability

Clinical and Translational Science
Genetic variants in drug transporter genes shape the interindividual variability in drug response. However, their functional interpretation has remained limited due to the substrate dependence of variant effects.
Yoomi Park, Yitian Zhou, Ming Xiao, Anne T. Nies, Volker M. Lauschke   +4 more
doaj   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Ergogenic and Sympathomimetic Effects of Yohimbine: A Review

Neurology International
The purpose of this review is to compile and discuss available evidence in humans on the efficacy of YHM supplementation on performance in different exercise modalities.
Sophia L. Porrill, Rebecca R. Rogers, Christopher G. Ballmann   +2 more
doaj   +1 more source

Cardiovascular Organoids With Adjustable Endothelial Composition via SOX17‐Engineered hPSCs

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Organoids are considered a novel modeling platform for studying human biology and advancing health research. With the ability to demonstrate complex 3D structure and multicellular interactions, organoids have advanced studies in all major organs as a reliable model.
Po‐Yu Liang, Gyuhyung Jin, Nathan R. Petrucci, Xiaojun Lance Lian, Xiaoping Bao   +4 more
wiley   +1 more source

THE GLYCEMIC POTENTIALS OF NONCATECHOL SYMPATHOMIMETICS IN SELECTED IN VIVO AND IN VITRO MODEL SYSTEMS [PDF]

, 1983
The influence of noncatechol sympathomimetics (NCSPM) on glucose metabolism in in vivo and in vitro systems was examined. Ephedrine (EPD) and phenylpropanolamine (PPA) lowered post-challenge glucose levels in fed mice following an oral glucose load of 2 ...
PARKER, VERNON DWAYNE
core  

Elucidating the outpatient burden of lower respiratory tract infections due to RSV and other viruses in children under 2 years of age: Clinical presentation, medical treatment, and family impact (Germany, 11/2022-10/2024)

International Journal of Infectious Diseases
Objectives: Worldwide, data on the burden of pediatric, outpatient-treated lower respiratory tract infections (LRTI) are limited. We investigated their viral etiology, clinical characteristics and family impact in Würzburg/Germany. Methods: Children aged
Katharina J. Hecker, Hanna Bethe, Géraldine Engels, Kerstin Knies, Christine Krempl, Benedikt Weissbrich, Johannes Liese, Andrea Streng, Wolfgang Brosi, Elke Brosi, Simon Berzel, Kathrin Heinke, Henrike Zillhardt, Gabriele Lieb, Uwe Sack, Silvia Glotzbach-Sack, Margarethe Kozuschek, Johannes Hausmann, Anna Weber, Stephan Jarosch, Manuel Langer, Annette Hein, Martin Herbst, Heike Backmann, Anna-Teresa Schneiderbanger, Roland Metzner, Christa Kitz   +26 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Programming the Optoelectronic Properties of Atomically Precise Gold Nanoclusters Using the Conformational Landscape of Intrinsically Disordered Proteins

Chemistry – A European Journal, EarlyView.
ABSTRACT The rational design of hybrid nanomaterials with precisely controlled properties remains a central challenge in materials science. While atomically precise gold nanoclusters (Au‐NCs) offer molecule‐like control over a metallic core, tuning their optoelectronic behavior via surface engineering is often empirically driven.
Santiago Rodriguez, Sylvain Kumanski, Zeineb Ayed, Aurélie Fournet, Charlène Bouanchaud, Amin Sagar, Frédéric Allemand, Vladimir A. Baulin, Ute Resch‐Genger, Juan Cortés, Nathalie Sibille, Fabien Chirot, Karl David Wegner, Rodolphe Antoine, Xavier Le Guével, Pau Bernadó   +15 more
wiley   +1 more source

Mecanismos de cardiotoxicidad: antineoplásicos, anti-inflamatorios no esteroideos, antipsicóticos, cocaetileno y simpaticomiméticos Mechanisms of cardiotoxicity: antineoplastics, nonsteroidal anti-inflammatory drugs, antipsychotics, cocaethylene and sympathomimetics

Revista Colombiana de Cardiología, 2011
La interacción constante del organismo humano con diferentes sustancias, que incluso en muchas ocasiones se consideran inofensivas, tiene un alto impacto sobre todos los sistemas, siendo el cardiovascular uno de los más afectados.
Lukas Salazar, Ana Cristina Palacio, Javier R Rodríguez   +2 more
doaj  

Ensuring optimal metabolism during coronary artery bypass grafting with cardiopulmonary bypass

Patologìâ
Aim: to reduce perioperative complications in cardiac surgeries with cardiopulmonary bypass (CPB) by developing a comprehensive, personalized approach to ensure optimal tissue metabolism. Materials and methods.
V. I. Cherniy, L. O. Sobanska
doaj   +1 more source