Results 71 to 80 of about 3,868 (289)

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Possibilities of pharmacological correction of the artifical bladder contractile activity in experimental conditions in vivo.

Medičnì Perspektivi, 2019
The aim of this work was to study the possibility of pharmacological correction of the neobladder contractile activity of mini-pigs under the influence of new chemical compounds, m-anticholinergic (solifenacin), selective beta-2 sympathomimetic (ginipral
R. V. Savchuk, F. I. Kostyev, N. V. Shmatkova   +2 more
doaj   +1 more source

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Delayed-onset drug-induced movement disorders

Psychiatry and Clinical Psychopharmacology, 2021
Delayed-onset drug-induced movement disorders (tardive syndromes) remain an important clinical problem. There are several phenomenologically and pharmacologically distinct types of tardive syndromes. The term tardive dyskinesia has been used to refer to
Oya Öztürk, Erhan Kurt, Timuçin Oral
doaj  

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio, Annabelle Wilcox, Stacey Cole, Josue Flores Daboub, José E. Morales Moreno, Kasey G. Andrews, S. Yukiko Asaki, Thomas A. Pilcher, Martin Tristani‐Firouzi, Mary C. Niu, David Viskochil, Benjamin Hammond   +11 more
wiley   +1 more source

Pediatrician’s cough and cold medication prescription for hypothetical cases – A cross-sectional multi-centric study

Saudi Pharmaceutical Journal, 2016
Background: Concerns over inappropriate use of cough and cold medication (CCM) in children have been raised. In addition to being ineffective, these are now considered toxic for young children.
Sudha Chandelia, Mukesh Dhankar, Meetu Salhan   +2 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Primary care respiratory syncytial virus disease characteristics in infants and young children in Germany: data from the prospective pediatric airway pathogen incidence surveillance network, 2021-2023

International Journal of Infectious Diseases
Objectives: Respiratory syncytial virus (RSV) is a major cause of morbidity globally, with most cases managed in outpatient settings. However, data characterizing the disease burden of non-severe RSV infections remain limited.
Alexander Kiefer, David Twardella, Jessica Bähre, Clemens Behrens, Thomas Buck, Frank Eberhardt, Mathieu Bangert, Rolf Kramer, Andrea Gerber, Martin Rosewich, Franziska Schaaff, Jan-Helge Höpner, Marcus Panning, Michael Kabesch, Christine Happle, Martin Wetzke   +15 more
doaj   +1 more source

The Efficiency of Epidural Anesthesia and Postoperative Analgesia during Myocardial Revascularization without Extracorporeal Circulation

Общая реаниматология, 2010
Objective: to evaluate the efficiency of high thoracic epidural anesthesia (EA) and analgesia during aortocoronary bypass surgery (ACBS) without extracorporeal circulation (EC). Subjects and methods.
A. V. Yeremeyev, A. A. Smetkin, M. Yu. Kirov   +2 more
doaj   +1 more source