Results 1 to 10 of about 34,958 (256)

CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1. [PDF]

Nature Communications, 2018
Na+-coupled acid-base transporters play essential roles in human biology. Their dysfunction has been linked to cancer, heart, and brain disease. High-resolution structures of mammalian Na+-coupled acid-base transporters are not available.
Abuladze, Natalia, Azimov, Rustam, Huynh, Kevin W, Jiang, Jiansen, Kao, Liyo, Kurtz, Ira, Newman, Debra, Pushkin, Alexander, Shao, Xuesi, Tsirulnikov, Kirill, Zhou, Z Hong   +10 more
core   +8 more sources

Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid?

International Journal of Endocrinology, 2018
Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism.
Meng Zhao, Xiaohan Zhang, Ling Gao, Yongfeng Song, Chao Xu, Chunxiao Yu, Shanshan Shao, Jiajun Zhao   +7 more
doaj   +2 more sources

Structure and function of the divalent anion/Na+ symporter from Vibrio cholerae and a humanized variant

Nature Communications, 2017
Divalent anion/Na+ symporter (DASS) transporters move intermediates of the Krebs cycle across the cell membrane. Here the authors present the substrate-bound structures of VcINDY, a DASS from Vibrio cholerae, which provide insights into the underlying ...
Rongxin Nie, Steven Stark, Jindrich Symersky, Ronald S. Kaplan, Min Lu   +4 more
doaj   +2 more sources

Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity

Nature Communications, 2016
UapA is a uric acid/xanthine H+symporter from a filamentous fungus. Here, the authors solve the crystal structure of the transporter in complex with xanthine revealing it to be a dimer, and this homodimerisation is proposed to be important for function.
Yilmaz Alguel, Sotiris Amillis, James Leung, George Lambrinidis, Stefano Capaldi, Nicola J. Scull, Gregory Craven, So Iwata, Alan Armstrong, Emmanuel Mikros, George Diallinas, Alexander D. Cameron, Bernadette Byrne   +12 more
doaj   +2 more sources

The extra-thyroidal distribution of sodium iodide symporter [PDF]

Frontiers in Endocrinology
The intrinsic transmembrane protein known as sodium iodide symporter (NIS) facilitates the active transport of iodide across the basolateral membrane of thyroid follicular cells.
Rinae Prisca Gadisi, Meleshni Naicker, Strinivasen Naidoo   +2 more
doaj   +2 more sources

Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh

eLife, 2018
Many secondary active membrane transporters pump substrates against concentration gradients by coupling their uptake to symport of sodium ions. Symport requires the substrate and ions to be always transported together.
SeCheol Oh, Olga Boudker
doaj   +2 more sources

Dimerization of the Sodium/Iodide Symporter

Thyroid, 2019
Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Thompson, Rebecca J., Fletcher, Alice, Brookes, Katie, Nieto, Hannah, Alshahrani, Mohammed M., Mueller, Jonathan W., Fine, Nicholas H.F., Hodson, David J., Boelaert, Kristien, Read, Martin L., Smith, Vicki E., McCabe, Christopher J.   +11 more
openaire   +3 more sources

Lactose Permease Scrambles Phospholipids

Biology, 2023
Lactose permease (LacY) from Escherichia coli belongs to the major facilitator superfamily. It facilitates the co-transport of β-galactosides, including lactose, into cells by using a proton gradient towards the cell.
Lei Wang, Peter Bütikofer
doaj   +1 more source

Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS

Theranostics, 2021
The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of sodium iodide symporter (NIS), diminished targeting of NIS to the cell membrane,
J. Oh, B. Ahn
semanticscholar   +1 more source

Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H+ symporter STP10

Nature Plants, 2021
Sugars are essential sources of energy and carbon and also function as key signalling molecules in plants. Sugar transport proteins (STP) are proton-coupled symporters responsible for uptake of glucose from the apoplast into plant cells.
Laust Bavnhøj, P. A. Paulsen, J. C. Flores-Canales, B. Schiøtt, B. P. Pedersen   +4 more
semanticscholar   +1 more source