Results 1 to 10 of about 13,309 (119)

Anion Selectivity by the Sodium Iodide Symporter [PDF]

Endocrinology, 2003
Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline, Massart, Claude, Beauwens, Renaud, Schoutens, André, Costagliola, Sabine, Dumont, Jacques Emile, Wolff, J   +6 more
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A chemiosmotic mechanism of symport [PDF]

Proceedings of the National Academy of Sciences, 2015
Lactose permease (LacY), a paradigm for the largest family of membrane transport proteins, catalyzes the coupled translocation of a galactoside and an H + across the Escherichia coli membrane (galactoside/H + symport).
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A symporter’s secrets shown [PDF]

Journal of General Physiology, 2017
New JGP study explores the thermodynamic cycle and cation preference of the sugar symporter MelB.
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Dimerization of the Sodium/Iodide Symporter

Thyroid, 2019
Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Mohammed Alshahrani, Mohammed Alshahrani, Jonathan W. Mueller, Jonathan W. Mueller, Christopher McCabe, Christopher McCabe, Katie Brookes, Katie Brookes, Rebecca Thompson, Rebecca Thompson, David J. Hodson, David J. Hodson, Martin L. Read, Martin L. Read, Hannah Nieto, Hannah Nieto, Kristien Boelaert, Kristien Boelaert, Nicholas H. F. Fine, Nicholas H. F. Fine, Vicki Smith, Vicki Smith, Alice Fletcher, Alice Fletcher   +23 more
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Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium Symporters

The Journal of Physical Chemistry B, 2017
Dimerization is a common feature among the members of the neurotransmitter:sodium symporter (NSS) family of membrane proteins. Yet, the effect of dimerization on the mechanism of action of NSS members is not fully understood. In this study, we examined the collective dynamics of two members of the family, leucine transporter (LeuT) and dopamine ...
Mert Gur, Mary Hongying Cheng, Elia Zomot, Ivet Bahar   +3 more
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Gating Topology of the Proton-Coupled Oligopeptide Symporters [PDF]

Structure, 2015
Proton-coupled oligopeptide transporters belong to the major facilitator superfamily (MFS) of membrane transporters. Recent crystal structures suggest the MFS fold facilitates transport through rearrangement of their two six-helix bundles around a central ligand binding site; how this is achieved, however, is poorly understood.
Jane Kwok, Anthony Watts, Philip W. Fowler, Martin Caffrey, Nicolae Solcan, Marcella Orwick-Rydmark, Joseph A. Lyons, Lucy R. Forrest, Simon Newstead, Patricia M. Dijkman, Sebastian Radestock   +10 more
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About P systems with symport/antiport [PDF]

Soft Computing, 2004
It is proved that four membranes su±ce to P systems with minimal symport/antiport to generate all recursively enumerable sets of numbers. It is also proved that P systems with symport/antiport without maximal par- allelism are equivalent to partially blind counter automata.
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A potassium-proton symport in Neurospora crassa. [PDF]

The Journal of general physiology, 1986
Combined ion flux and electrophysiological measurements have been used to characterized active transport of potassium by cells of Neurospora crassa that have been moderately starved of K+ and then maintained in the presence of millimolar free calcium ions.
Michael R. Blatt, Alonso Rodríguez-Navarro, Clifford L. Slayman   +2 more
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Expression of the sodium iodide symporter in human kidney [PDF]

Kidney International, 2001
The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland. Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.The aim of ...
Charyl M. Dutton, Maria R. Castro, John C. Morris, Elizabeth R. Bergert, John R. Goellner, Armin E. Heufelder, Christine Spitzweg   +6 more
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Symport and antiport mechanisms of human glutamate transporters

Nature Communications, 2023
AbstractExcitatory amino acid transporters (EAATs) uptake glutamate into glial cells and neurons. EAATs achieve million-fold transmitter gradients by symporting it with three sodium ions and a proton, and countertransporting a potassium ion via an elevator mechanism. Despite the availability of structures, the symport and antiport mechanisms still need
Biao Qiu, Olga Boudker
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