Results 101 to 110 of about 34,958 (256)

Astrocytes and neurons communicate via a monocarboxylic acid shuttle [PDF]

, 2020
Since formulation of the Astrocyte-Neuron Lactate Shuttle (ANLS) hypothesis in 1994, the hypothesis has provoked criticism and debate. Our review does not criticise, but rather integrates experimental data characterizing proton-linked monocarboxylate ...
Cottrell, Graeme S., Roosterman, Dirk
core   +1 more source

Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack

New Phytologist, Volume 249, Issue 3, Page 1124-1144, February 2026.
Summary NRT1/PTR FAMILY (NPF) transporters play crucial roles in plant physiology and development due to their involvement in nitrogen nutrition and their ability to transport multiple signaling molecules and metabolites. Whereas most eukaryotic and prokaryotic NPF orthologs are peptide transporters, most flowering plant NPF transport other substrates ...
Laura Morales de Los Ríos, The Dan Pham, Thibaut Perez, Myriam Ben Amar, Claire Corratgé‐Faillie, François Barbier, Benoit Lacombe   +6 more
wiley   +1 more source

Multiple Myeloma : an update on disease biology and therapy [PDF]

, 2004
Multiple myeloma is a malignancy of immunoglobulin producing plasma cells. Clinical features include bone pain due to lytic bone lesions or pathological fractures, anemia, symptomatic hypercalcemia, renal insufficiency, recurrent infections and ...
Cook, Rachel J., Dingli, David
core  

NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]

, 2018
Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena, Bongiovanni, Massimo, Carrasco, Nancy, Chartoumpekis, Dionysios V, Habeos, Ioannis, Juvenal, Guillermo Juan, Kensler, Thomas W., Liao, Xiao-Hui, Ntalampyra, Eleni, Refetoff, Samuel, Renaud, Cédric O., Ris Stalpers, Carrie, Rossich, Luciano Esteban, Santisteban, Pilar, Somm, Emmanuel, Sykiotis, Gerasimos P., Thomasz, Lisa, Trougakos, Ioannis P, Yamamoto, Masayuki, Ziros, Panos G   +19 more
core   +1 more source

Structural basis of proton-coupled potassium transport in the KUP family [PDF]

, 2020
Potassium homeostasis is vital for all organisms, but is challenging in single-celled organisms like bacteria and yeast and immobile organisms like plants that constantly need to adapt to changing external conditions.
Aumüller, Nadine, Corey, Robin A., Griwatz, David, Hänelt, Inga, Mikusevic, Vedrana, Mills, Deryck J., Sousa, Joana S., Stansfeld, Phillip J., Tascón, Igor, Vonck, Janet   +9 more
core   +2 more sources

Structural basis for substrate binding and specificity of a sodium–alanine symporter AgcS

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The substrate binding and specificity are essential features for the amino acid–polyamine–organocation superfamily members. Here, we report two crystal structures of an alanine transporter, alanine or glycine:cation symporter, capable of ...
Jinming Ma, H. Lei, F. Reyes, Silvia Sánchez-Martínez, Maen F. Sarhan, J. Hattne, T. Gonen   +6 more
semanticscholar   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Effective carbon partitioning driven by exotic phloem-specific regulatory elements fused to the Arabidopsis thaliana AtSUC2 sucrose-proton symporter gene

BMC Plant Biology, 2009
Background AtSUC2 (At1g22710) from Arabidopsis thaliana encodes a phloem-localized sucrose/proton symporter required for efficient photoassimilate transport from source tissues to sink tissues.
Ismail Ihab O, Ganesan Savita, Srivastava Avinash C, Ayre Brian G   +3 more
doaj   +1 more source

Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells [PDF]

, 2015
The aetiology of human fibrolamellar hepatocellular carcinomas (hFL-HCCs), cancers occurring increasingly in children to young adults, is poorly understood.
ALVARO, Domenico, CARDINALE, VINCENZO, Carpino, Guido, Carrasco, Nancy, Dinh, Timothy A., GAUDIO, EUGENIO, Klimstra, David, Levine, Ronald, Oikawa, Tsunekazu, Reid, Lola M., Reyna Neyra, Andrea, Selitsky, Sara R., Sethupathy, Praveen, Wauthier, Eliane   +13 more
core   +2 more sources

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source