Results 11 to 20 of about 34,004 (309)

The extra-thyroidal distribution of sodium iodide symporter [PDF]

Frontiers in Endocrinology
The intrinsic transmembrane protein known as sodium iodide symporter (NIS) facilitates the active transport of iodide across the basolateral membrane of thyroid follicular cells.
Rinae Prisca Gadisi, Meleshni Naicker, Strinivasen Naidoo   +2 more
doaj   +2 more sources

Dimerization of the Sodium/Iodide Symporter

Thyroid, 2019
Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become ...
Rebecca J. Thompson, A. Fletcher, Katie Brookes, H. Nieto, Mohammed Alshahrani, Jonathan Wolf Mueller, N. Fine, D. Hodson, K. Boelaert, Martin L Read, V. Smith, C. McCabe   +11 more
semanticscholar   +4 more sources

Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity

Nature Communications, 2016
UapA is a uric acid/xanthine H+symporter from a filamentous fungus. Here, the authors solve the crystal structure of the transporter in complex with xanthine revealing it to be a dimer, and this homodimerisation is proposed to be important for function.
Yilmaz Alguel, Sotiris Amillis, James Leung, George Lambrinidis, Stefano Capaldi, Nicola J. Scull, Gregory Craven, So Iwata, Alan Armstrong, Emmanuel Mikros, George Diallinas, Alexander D. Cameron, Bernadette Byrne   +12 more
doaj   +2 more sources

Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid?

International Journal of Endocrinology, 2018
Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism.
Meng Zhao, Xiaohan Zhang, Ling Gao, Yongfeng Song, Chao Xu, Chunxiao Yu, Shanshan Shao, Jiajun Zhao   +7 more
doaj   +2 more sources

Structure and function of the divalent anion/Na+ symporter from Vibrio cholerae and a humanized variant

Nature Communications, 2017
Divalent anion/Na+ symporter (DASS) transporters move intermediates of the Krebs cycle across the cell membrane. Here the authors present the substrate-bound structures of VcINDY, a DASS from Vibrio cholerae, which provide insights into the underlying ...
Rongxin Nie, Steven Stark, Jindrich Symersky, Ronald S. Kaplan, Min Lu   +4 more
doaj   +2 more sources

Molecular dynamics simulations of the bacterial UraA H+-uracil symporter in lipid bilayers reveal a closed state and a selective interaction with cardiolipin.

PLoS Computational Biology, 2015
The Escherichia coli UraA H+-uracil symporter is a member of the nucleobase/ascorbate transporter (NAT) family of proteins, and is responsible for the proton-driven uptake of uracil.
Antreas C Kalli, Mark S P Sansom, Reinhart A F Reithmeier   +2 more
doaj   +2 more sources

Sodium Iodide Symporter (NIS) and Thyroid [PDF]

HORMONES, 2002
idase (TPO) and incorporation into tyrosyl residues along the thyroglobulin (Tg) backbone. The thyroid hormones T3 and T4 are synthesized by coupling of two iodotyrosine residues and stored in the colloid. All of these steps are stimulated by pituitary-derived thyroid stimulating hormone (TSH), which interacts with the TSH receptor at the basolateral ...
Christine Spitzweg, John C. Morris
openalex   +3 more sources

Structural insights into the elevator-like mechanism of the sodium/citrate symporter CitS

Scientific Reports, 2017
The sodium-dependent citrate transporter of Klebsiella pneumoniae (KpCitS) belongs to the 2-hydroxycarboxylate transporter (2-HCT) family and allows the cell to use citrate as sole carbon and energy source in anaerobic conditions. Here we present crystal
Ji Won Kim, Subin Kim, Songwon Kim, Haerim Lee, Jie-Oh Lee, Mi Sun Jin   +5 more
doaj   +2 more sources

Lactose Permease Scrambles Phospholipids

Biology, 2023
Lactose permease (LacY) from Escherichia coli belongs to the major facilitator superfamily. It facilitates the co-transport of β-galactosides, including lactose, into cells by using a proton gradient towards the cell.
Lei Wang, Peter Bütikofer
doaj   +1 more source

Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS

Theranostics, 2021
The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of sodium iodide symporter (NIS), diminished targeting of NIS to the cell membrane,
J. Oh, B. Ahn
semanticscholar   +1 more source