Characterization of new polyol/H+ symporters in Debaryomyces hansenii. [PDF]
PLoS ONE, 2014 Debaryomyces hansenii is a halotolerant yeast that produces and assimilates a wide variety of polyols. In this work we evaluate polyol transport in D. hansenii CBS 767, detecting the occurrence of polyol/H(+) (and sugar/H(+)) symporter activity, through ...
Iliana Pereira +4 more
doaj +1 more source
ZrFsy1, a high-affinity fructose/H+ symporter from fructophilic yeast Zygosaccharomyces rouxii. [PDF]
PLoS ONE, 2013 Zygosaccharomyces rouxii is a fructophilic yeast than can grow at very high sugar concentrations. We have identified an ORF encoding a putative fructose/H(+) symporter in the Z. rouxii CBS 732 genome database.
Maria José Leandro +3 more
doaj +1 more source
OncoTargets and Therapy, 2021 Objective To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation.
T. Anekpuritanang +5 more
semanticscholar +1 more source
Resveratrol inhibits sodium/iodide symporter gene expression and function in rat thyroid cells. [PDF]
PLoS ONE, 2014 Resveratrol is a polyphenol found in grapes and berries that has antioxidant, antiproliferative and anti-inflammatory properties. For these reasons, it is available as a dietary supplement, and it is under investigation in several clinical trials.
Cesidio Giuliani +8 more
doaj +1 more source
Structural basis for proton coupled cystine transport by cystinosin
Nature Communications, 2022 Mutations in CTNS, the lysosomal cystine-proton symporter, cause cystinosis. Here authors report crystal structures of CTNS from Arabidopsis thaliana in complex with cystine, and establish the mode of ligand recognition and mechanism for proton-coupled ...
Mark Löbel +6 more
doaj +1 more source
Novel insights into the Thaumarchaeota in the deepest oceans: their metabolism and potential adaptation mechanisms [PDF]
, 2020 Background: Marine Group I (MGI) Thaumarchaeota, which play key roles in the global biogeochemical cycling of nitrogen and carbon (ammonia oxidizers), thrive in the aphotic deep sea with massive populations.
Lehtovirta-Morley, Laura +8 more
core +2 more sources
Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate
Nature Structural & Molecular Biology, 2020 The Na+/I− symporter (NIS), the plasma membrane protein that actively transports I− (stoichiometry 2Na+:1I−) in thyroid physiology and radioiodide-based thyroid cancer treatment, also transports the environmental pollutant perchlorate (stoichiometry 1Na+:
UC Irvine +2 more
semanticscholar +1 more source
Tumor microenvironment affects exogenous sodium/iodide symporter expression
Translational Oncology, 2021 For decades, sodium/iodide symporter NIS-mediated iodide uptake has played a crucial role in the radioactive ablation of thyroid cancer cells. NIS-based gene therapy has also become a promising tool for the treatment of tumors of extrathyroidal origin ...
Fabio Castillo-Rivera +9 more
doaj +1 more source
Heliyon, 2021 The popular recreational drug MDMA (3,4-methylenedioxy-methamphetamine) has a documented potential as a psychopharmacological clinical and research tool.
Ángel A. Islas +2 more
doaj +1 more source
Distribution and dynamics of Tc-99m-pertechnetate uptake in the thyroid and other organs assessed by single-photon emission computed tomography in living mice [PDF]
, 2010 Background: Tc-99m pertechnetate is a well-known anion, used for clinical imaging of thyroid function. This gamma emitter is transported by the sodium iodide symporter but is not incorporated into thyroglobulin. Scintigraphy using Tc-99m pertechnetate or
Darcourt, Jacques +6 more
core +1 more source