Results 21 to 30 of about 34,004 (309)
Nature Plants, 2021 Sugars are essential sources of energy and carbon and also function as key signalling molecules in plants. Sugar transport proteins (STP) are proton-coupled symporters responsible for uptake of glucose from the apoplast into plant cells.
Laust Bavnhøj +4 more
semanticscholar +1 more source
The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment.
Endocrine-Related Cancer, 2021 Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter in molecular thyroidology with the characterization of NIS as one of the most powerful theranostic genes and the development of a promising gene therapy strategy ...
C. Spitzweg +7 more
semanticscholar +1 more source
OncoTargets and Therapy, 2021 Objective To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation.
T. Anekpuritanang +5 more
semanticscholar +1 more source
Characterization of new polyol/H+ symporters in Debaryomyces hansenii. [PDF]
PLoS ONE, 2014 Debaryomyces hansenii is a halotolerant yeast that produces and assimilates a wide variety of polyols. In this work we evaluate polyol transport in D. hansenii CBS 767, detecting the occurrence of polyol/H(+) (and sugar/H(+)) symporter activity, through ...
Iliana Pereira +4 more
doaj +1 more source
ZrFsy1, a high-affinity fructose/H+ symporter from fructophilic yeast Zygosaccharomyces rouxii. [PDF]
PLoS ONE, 2013 Zygosaccharomyces rouxii is a fructophilic yeast than can grow at very high sugar concentrations. We have identified an ORF encoding a putative fructose/H(+) symporter in the Z. rouxii CBS 732 genome database.
Maria José Leandro +3 more
doaj +1 more source
Resveratrol inhibits sodium/iodide symporter gene expression and function in rat thyroid cells. [PDF]
PLoS ONE, 2014 Resveratrol is a polyphenol found in grapes and berries that has antioxidant, antiproliferative and anti-inflammatory properties. For these reasons, it is available as a dietary supplement, and it is under investigation in several clinical trials.
Cesidio Giuliani +8 more
doaj +1 more source
Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential. [PDF]
J PatholAbstract Lung cancer is the leading cause of cancer‐related death globally. To better understand the biology of lung cancer, mouse models have been developed using either tail vein‐injected tumour cell lines or genetically modified mice. The current gold‐standard models typically present with multiple lung foci.
Pedrosa AR +20 more
europepmc +2 more sources
Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate
Nature Structural & Molecular Biology, 2020 The Na+/I− symporter (NIS), the plasma membrane protein that actively transports I− (stoichiometry 2Na+:1I−) in thyroid physiology and radioiodide-based thyroid cancer treatment, also transports the environmental pollutant perchlorate (stoichiometry 1Na+:
UC Irvine +2 more
semanticscholar +1 more source
Structural basis for proton coupled cystine transport by cystinosin
Nature Communications, 2022 Mutations in CTNS, the lysosomal cystine-proton symporter, cause cystinosis. Here authors report crystal structures of CTNS from Arabidopsis thaliana in complex with cystine, and establish the mode of ligand recognition and mechanism for proton-coupled ...
Mark Löbel +6 more
doaj +1 more source
Anion Selectivity by the Sodium Iodide Symporter [PDF]
Endocrinology, 2003 Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline +6 more
openaire +2 more sources