Results 21 to 30 of about 15,584 (224)
Dimerization of the Sodium/Iodide Symporter
Thyroid, 2019 Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Mohammed Alshahrani +23 more
openaire +3 more sources
mSphere, 2019 Inorganic pyrophosphate (PPi) is a by-product of biosynthetic reactions and has bioenergetic and regulatory roles in a variety of cells. Here we show that PPi and other pyrophosphate-containing compounds, including polyphosphate (polyP), can stimulate ...
Evgeniy Potapenko +3 more
doaj +1 more source
Seaweed and Iodine Intakes and rs77277498 in Relation to Thyroid Cancer [PDF]
Endocrinology and Metabolism, 2022 Background This study aims to elucidate the associations among dietary seaweed (gim and miyeok/dashima) and iodine intakes, the rs77277498 polymorphism of the SLC5A5 gene codifying the sodium/iodine symporter, and thyroid cancer risk in a Korean ...
Tung Hoang +4 more
doaj +1 more source
New Choice for Small Universal Devices: Symport/Antiport P Systems [PDF]
EPTCS 1, 2009, pp. 235-242, 2009 Symport/antiport P systems provide a very simple machinery inspired by corresponding operations in the living cell. It turns out that systems of small descriptional complexity are needed to achieve the universality by these systems. This makes them a good candidate for small universal devices replacing register machines for different simulations ...
arxiv +1 more source
Frontiers in Endocrinology, 2021 Background and ObjectivesDefects in the human sodium/iodide symporter (SLC5A5) gene have been reported to be one of the causes of congenital hypothyroidism (CH).
Cao-Xu Zhang +12 more
doaj +1 more source
Metadynamics simulations reveal a Na+ independent exiting path of galactose for the inward-facing conformation of vSGLT. [PDF]
PLoS Computational Biology, 2014 Sodium-Galactose Transporter (SGLT) is a secondary active symporter which accumulates sugars into cells by using the electrochemical gradient of Na+ across the membrane. Previous computational studies provided insights into the release process of the two
Ina Bisha +3 more
doaj +1 more source
Mutational analysis of the respiratory nitrate transporter NarK2 of Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2012 Mycobacterium tuberculosis induces nitrate reductase activity in response to decreasing oxygen levels. This is due to regulation of both the transcription and the activity of the nitrate transporter NarK2.
Michelle M Giffin +3 more
doaj +1 more source
Frontiers in Microbiology, 2022 The SLC5/STAC histidine kinases comprise a recently identified family of sensor proteins in two-component signal transduction systems (TCSTS), in which the signaling domain is fused to an SLC5 solute symporter domain through a STAC domain.
Ana Laura Ramos +16 more
doaj +1 more source
Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium Symporters
The Journal of Physical Chemistry B, 2017 Dimerization is a common feature among the members of the neurotransmitter:sodium symporter (NSS) family of membrane proteins. Yet, the effect of dimerization on the mechanism of action of NSS members is not fully understood. In this study, we examined the collective dynamics of two members of the family, leucine transporter (LeuT) and dopamine ...
Mert Gur +3 more
openaire +4 more sources
Gating Topology of the Proton-Coupled Oligopeptide Symporters [PDF]
Structure, 2015 Proton-coupled oligopeptide transporters belong to the major facilitator superfamily (MFS) of membrane transporters. Recent crystal structures suggest the MFS fold facilitates transport through rearrangement of their two six-helix bundles around a central ligand binding site; how this is achieved, however, is poorly understood.
Jane Kwok +10 more
openaire +5 more sources